Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.7 (
acetylcholinesterase
)
28,390
document(s) hit in 31,850,051 MEDLINE articles (0.04 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
acetylcholinesterase
20812
butyrylcholinesterase
2506
Sep
1972
AChE
1534
choline acetyltransferase
1238
Mol
869
catalase
858
superoxide dismutase
722
esterase
616
muscarinic receptor
476
amyloid precursor protein
434
GSH
427
ATPase
419
alkaline phosphatase
417
NMR
413
Cholinesterase
409
lactate dehydrogenase
389
glutathione S-transferase
380
glutathione peroxidase
373
carboxylesterase
372
acetylcholine receptor
326
albumin
323
axonal
318
nicotinic acetylcholine receptor
279
membrane-bound
268
CA1
255
collagen
246
substance P
244
tyrosine hydroxylase
240
pseudocholinesterase
228
peroxidase
225
aspartate aminotransferase
224
nerve growth factor
215
hemoglobin
201
olfactory
200
alanine aminotransferase
199
serum albumin
194
GABA
188
ATP
183
polypeptide
181
glucosidase
181
glutathione reductase
168
TNF
168
tyrosinase
167
caspase-3
164
amylase
162
insulin
162
acid phosphatase
158
amyloid beta
154
NMDA receptor
152
endoplasmic reticulum
148
brain-derived neurotrophic factor
145
microsomal
144
somatostatin
142
cytochrome P450
139
Choline acetyltransferase
136
glial fibrillary acidic protein
135
nitric oxide synthase
133
paraoxonase
127
tumor necrosis factor
119
SDS
113
CA3
112
gut
110
neuropathy target esterase
108
SOD
105
cytokine
105
alpha-fetoprotein
105
ESI
104
dimeric
103
muscarinic acetylcholine receptor
102
calcitonin
102
ACS
101
MAO-B
100
BACE1
98
5-hydroxytryptamine
97
AMP
95
CAT
95
neuropeptide Y
91
creatine kinase
89
GST
89
lipopolysaccharide
89
lipase
88
metallothionein
86
5'-nucleotidase
84
calbindin
83
IL-6
82
Gen
81
antioxidant enzyme
81
diaphorase
80
prothrombin
79
Pol
79
carbonic anhydrase
79
carp
78
arylesterase
77
MAO-A
76
glycoprotein
76
megakaryocyte
74
glucose-6-phosphate dehydrogenase
74
collagenase
73
thymus
72
ROS
71
Bcl-2
71
vesicular acetylcholine transporter
70
phosphodiesterase
70
LDH
70
ACHE
69
cytochrome
69
ADAS
69
parvalbumin
67
tau protein
67
NADPH
65
APP
65
DDT
64
FRAP
63
CSF
63
xenobiotic
63
lipoxygenase
62
erythroid
62
growth hormone
61
vasoactive intestinal peptide
60
phosphatidylinositol-specific
59
glutamic acid decarboxylase
59
synaptophysin
57
fused
56
myeloperoxidase
56
adenosine triphosphatase
56
interleukin-6
55
ChAT
55
lectin
54
hole
53
inducible nitric oxide synthase
53
calretinin
53
adenylate cyclase
53
P450
52
choline transporter
52
membrane protein
51
NADH
51
PAM
51
MRI
50
AChR
50
neurotrophic factor
50
TOF
49
AST
49
Pseudomonas
49
CAS
48
beta-endorphin
48
Carboxylesterase
48
Rec
48
BACE
47
vasoactive intestinal peptide (VIP)
47
brain)
46
transferrin
46
proline-rich
46
calcium channel
45
GABA(A) receptor
45
thyroid hormone
44
agrin
44
GPT
43
neurotrophin
43
SAR
43
more...
Disease
Alzheimer's disease
4380
dementia
1328
cognitive impairment
709
depression
552
GSH
427
memory impairment
367
Parkinson's disease
352
neuroblastoma
299
cancer
291
myasthenia gravis
288
diabetes
269
fits
189
tumor
165
amnesia
156
cirrhosis
155
psychosis
130
plaque
130
schizophrenia
119
neuropathy
113
SDS
113
Evans
108
hallucinations
105
hypertension
103
epilepsy
101
ischemia
100
varices
97
stroke
93
cognitive deficit
88
worms
88
Huntington's disease
85
cold
78
malaria
77
obesity
73
Dementia with Lewy bodies
73
myasthenia
68
parkinsonism
67
respiratory failure
66
hepatocellular carcinoma
66
status epilepticus
64
SEM
64
senile dementia
63
leukemia
63
liver disease
61
pheochromocytoma
60
hyperglycemia
58
malnutrition
54
Down syndrome
54
delusions
53
myopathy
51
delirium
51
PAM
51
glaucoma
48
autoimmune disease
47
multiple sclerosis
46
prolapse
46
type 2 diabetes
46
anemia
45
West
45
MCF
44
asthma
44
SAR
43
SCH
42
suicide
42
heart failure
41
carcinoma
41
dysplasia
40
amyotrophic lateral sclerosis
39
uterus
38
cardiovascular disease
38
chronic hepatitis
38
hypothyroidism
37
breast cancer
36
HIV
35
cerebral ischemia
34
hepatitis
34
coma
33
sepsis
32
plague
32
aggression
32
muscular dystrophy
31
sepsis
31
paroxysmal nocturnal hemoglobinuria
30
tetanus
30
polyneuropathy
30
confusion
30
thrombocytopenia
29
encephalopathy
28
dengue
27
mole
27
NAME
27
thymoma
27
myocardial infarction
27
Best
27
Vascular dementia
26
lung cancer
26
autism
26
fatty liver
26
diplopia
26
mental illness
26
major depressive disorder
25
hyperlipidemia
25
mole
25
chronic liver disease
24
Steroids
24
progressive supranuclear palsy
24
hypercholesterolemia
23
atherosclerosis
23
cornea
23
schistosomiasis
23
DBA
23
Schistosoma mansoni
22
neurological disease
22
disinhibition
22
dysphagia
22
TEM
22
addiction
22
sleep disorders
21
vascular disease
21
amyloidosis
20
TEM
20
bowel obstruction
20
PND
19
glioma
19
Enzyme inhibition
19
bipolar disorder
19
Thymus
19
Duchenne muscular dystrophy
19
PDB
19
Thymus
19
sleep disturbances
19
Thymus
19
hyperhomocysteinemia
19
dehydration
18
hepatitis B
18
incontinence
18
pneumonia
18
liver cancer
18
dyspepsia
17
PDE
17
NMS
17
intraocular pressure
17
catalepsy
17
brain atrophy
17
hyperthyroidism
17
tumorigenesis
17
pulmonary edema
17
peripheral neuropathy
17
megacolon
16
abortion
16
melanoma
16
Syndrome
16
psychological stress
16
brain dysfunction
16
NMS
16
CNS diseases
16
cholestasis
16
urethra
16
PCP
16
pertussis
15
posttraumatic stress disorder
15
more...
Symptom
seizures
343
anesthesia
260
weakness
235
memory loss
136
pain
113
diarrhea
103
vomiting
90
tremor
88
hypothermia
85
ACHE
84
nausea
84
agitation
79
fatigue
71
headache
62
ataxia
60
constipation
53
apathy
51
analgesia
43
functional recovery
43
dizziness
42
respiratory distress
40
fasciculation
33
syncope
30
collapse
27
insomnia
26
sleepiness
26
anorexia
26
dyspnea
23
exhaustion
22
abdominal pain
21
nausea and vomiting
19
chronic constipation
19
twitching
18
dystonia
18
incoordination
18
cough
18
acute stress
16
splenomegaly
15
starvation
15
blurred vision
15
lethargy
14
skin irritation
13
myalgia
12
visual hallucination
12
overweight
11
ophthalmoplegia
11
erythema
11
Ill
11
paresis
11
spasm
11
hypercapnia
10
acidity
10
thinning
10
bradykinesia
10
asthenia
9
hypotonia
9
spasticity
9
rhinorrhea
9
paresthesia
9
muscle cramps
8
myoclonus
8
despair
8
flushing
8
discomfort
6
Depressive symptoms
6
vertigo
6
loss of equilibrium
6
angina
5
dysarthria
5
numbness
5
epigastric pain
5
Decreased activity
5
heartburn
5
discomfort
4
cyanosis
4
hepatomegaly
4
Behavioral symptoms
4
wheezing
4
hypoproteinemia
4
forgetfulness
4
shortness of breath
4
rundown
4
pallor
4
colic
4
Sedation
4
ENT
4
torticollis
3
masculinization
3
cancer pain
3
chills
3
polydipsia
3
motor symptom
3
abdominal cramps
3
bloating
3
skin damage
3
chest pain
3
blepharospasm
3
Gastrointestinal symptoms
3
chorea
3
dry skin
3
regurgitation
3
sore throat
3
hyperoxia
3
chest tightness
3
Hudson
3
arthralgia
3
stigma
3
lightheadedness
3
cerebellar ataxia
2
nasal discharge
2
hunger
2
hypocapnia
2
hyperesthesia
2
frequent urination
2
abnormal gait
2
urinary frequency
2
tingling
2
Involuntary Movement
2
Fluctuation
2
leg cramps
2
leg pain
2
muscle stiffness
2
HSA
2
CSR
2
muscle rigidity
2
dysuria
2
consciousness disturbance
2
Cramping
2
emaciation
2
personality change
2
limb pain
2
abdominal discomfort
2
Postoperative pain
2
Wind
2
polyuria
2
loss of balance
2
rales
2
Deafferentation
2
prostration
2
giddiness
2
giddiness
2
excessive sweating
2
eds
2
tachypnea
2
back pain
2
testicular pain
1
tinnitus
1
hemiplegia
1
dental pain
1
hemoptysis
1
partial seizure
1
Psychiatric symptoms
1
hepatosplenomegaly
1
hot flashes
1
Burning
1
hot flushes
1
hypalgesia
1
stomach pain
1
distraction
1
Increased libido
1
more...
Drug
Donepezil
354
DFP
202
Atropine
170
vitamin E
107
Scopolamine
102
THA
94
CSF
71
ROS
71
Aricept
59
lysine
55
NADH
54
ascorbate
54
caffeine
50
Monit
45
Galanthamine
43
Ethanol
41
Pyridostigmine bromide
40
Glutathione
37
Pralidoxime
35
EDR
35
p75
34
Nephron
33
Gel
32
Pyridostigmine bromide
30
Vitamin E
24
EPA
24
Leaf
24
Dermatol
23
EE2
20
TAK
20
Exelon
20
Asn
19
Reminyl
18
CPT-11
18
Exelon
18
ENT
17
Cardiovasc
17
citric acid
16
IL-2
15
CTX
15
ZnO
15
Albumin
15
ALA
14
Ranitidine
13
Mestinon
13
PCP
13
Portal
13
HCH
13
Spectrum
12
Cognex
12
Biopolymers
12
Fraction
11
CaCl2
11
CaCl2
11
Clonidine
11
Piracetam
11
CaCl2
11
Distigmine bromide
11
Galantamine hydrobromide
11
Kainic acid
11
Tubocurarine
10
TAC
10
Ginseng
10
Ringer's solution
10
PCB
10
TiO2
9
Pilocarpine
9
Serum albumin
9
CoCl2
9
CoCl2
9
Irinotecan
9
Rutin
9
niacin
9
Indomethacin
9
Brij 96
9
MAP
8
MRC
8
DMAA
8
Forskolin
8
Reserpine
8
Fluorescein
8
Senna
8
Senna
8
Histamine
8
Mutagen
8
Capsicum
7
Gallamine
7
ROC
7
Frontal
7
lactose
7
Namenda
7
Triclosan
7
TTC
7
L-tyrosine
6
Phentolamine
6
CPO
6
IFN-gamma
6
Diphenhydramine
6
ABC
6
Ouabain
6
Retinoic acid
6
Papain
6
Pronase
6
Perindopril
6
Phenytoin
6
Cimetidine
6
Cimetidine
6
Bupivacaine
6
Propidium
5
Cisapride
5
Bisacodyl
5
ampicillin
5
Honey
5
OTC
5
Rocuronium
5
Dihydro
5
9-THC
5
Thyroglobulin
5
Azilect
5
Prednisone
5
Prostigmin
5
Atropine sulfate
5
Kenyan
5
Glycyrrhiza
5
Glide
5
Arsenic trioxide
4
Growth hormone
4
Azithromycin
4
G-CSF
4
Adenosine deaminase
4
Xylocaine
4
Rituximab
4
Angiotensin II
4
Idebenone
4
PTC
4
Camp
4
Growth hormone
4
CTX
4
1,8-Cineole
4
ETA
4
CTX
4
ICI
4
Ciclesonide
3
Glutamic acid
3
Marcaine
3
ZnCl2
3
Geranium
3
Sodium nitroprusside
3
NBT
3
Propentofylline
3
Areca
3
Tianeptine
3
Methylene blue
3
Cibacron Blue
3
OTC
3
Nephron
3
Tropicamide
3
Gastro
3
Captopril
3
Safflower
3
more...
Enzyme
acetylcholinesterase
28390
cholinesterase
11108
choline acetyltransferase
1266
catalase
901
superoxide dismutase
791
ATPase
479
glutathione S-transferase
443
alkaline phosphatase
432
lactate dehydrogenase
429
carboxylesterase
416
glutathione peroxidase
376
peroxidase
348
monoamine oxidase
324
alanine aminotransferase
315
aspartate aminotransferase
277
tyrosine hydroxylase
228
paraoxonase
171
glutathione reductase
167
tyrosinase
167
acid phosphatase
161
paraoxonase
150
NADPH-diaphorase
141
trypsin
137
caspase-3
126
choline oxidase
125
succinate dehydrogenase
117
creatine kinase
117
mitogen-activated protein kinase
117
neuropathy target esterase
114
protein kinase
114
gamma-glutamyl transpeptidase
111
diaphorase
111
cytochrome oxidase
104
ACS
101
phospholipase C
99
lipase
95
NQO1
87
glucose-6-phosphate dehydrogenase
86
carbonic anhydrase
85
5'-nucleotidase
85
protein kinase C
84
diaphorase
82
ERK
81
collagenase
74
phosphodiesterase
73
ACE
63
NO synthase
63
lipoxygenase
62
adenylate cyclase
55
chymotrypsin
51
PAM
51
succinic dehydrogenase
50
AST
48
phospholipase A2
47
glutamate dehydrogenase
45
glutamate dehydrogenase
45
glutamate dehydrogenase
45
GSK
44
glutamate decarboxylase
43
adenosine deaminase
43
adenosine deaminase
43
deaminase
43
urease
38
urease
38
aldolase
35
thrombin
35
hexokinase
33
arginase
33
malate dehydrogenase
33
phosphorylase
32
leucine aminopeptidase
31
CD10
31
CYP3A4
31
neuraminidase
29
lysozyme
29
isocitrate dehydrogenase
29
CPR
28
beta-secretase
28
dopamine beta-hydroxylase
28
glucose-6-phosphatase
27
beta-glucuronidase
26
xanthine oxidase
26
hyaluronidase
26
Mg2+-ATPase
26
cholesterol esterase
25
papain
25
hyaluronidase
24
beta-galactosidase
24
alpha-amylase
24
enolase
23
nucleotidase
23
complex I
22
PDE
22
pyruvate kinase
22
pepsin
22
NOS
22
isocitrate dehydrogenase
21
prolyl endopeptidase
20
focal adhesion kinase
19
glucose oxidase
19
caspase-9
18
ceruloplasmin
18
luciferase
18
delta-aminolevulinic acid dehydratase
18
alcohol dehydrogenase
18
glutamine synthetase
18
P-glycoprotein
17
PAH
16
PARP
16
demethylase
16
DFPase
16
alpha-glucosidase
16
AMPK
15
sorbitol dehydrogenase
15
monoacylglycerol lipase
15
renin
15
calcineurin
15
6-phosphogluconate dehydrogenase
14
6-phosphogluconate dehydrogenase
14
PCP
13
aldose reductase
13
citrate synthase
13
thromboplastin
13
phospholipase D
12
glyceraldehyde-3-phosphate dehydrogenase
12
adenylate kinase
12
elastase
12
reverse transcriptase
12
glyceraldehyde-3-phosphate dehydrogenase
12
DOPA decarboxylase
12
tyrosine aminotransferase
12
hexosaminidase
11
proteinase K
11
phosphofructokinase
11
glyceraldehyde-3-phosphate dehydrogenase
11
ornithine decarboxylase
11
RNase
11
RNase
11
phosphoglucomutase
11
glycerol-3-phosphate dehydrogenase
10
flavin-containing monooxygenase
10
CNPase
10
glyceraldehyde-3-phosphate dehydrogenase
10
MEK
10
phosphoinositide 3-kinase
10
UDP-glucuronosyltransferase
10
apyrase
10
glyceraldehyde-3-phosphate dehydrogenase
10
guanylate cyclase
10
transpeptidase
10
glycerol-3-phosphate dehydrogenase
10
proteasome
9
choline kinase
9
lactic acid dehydrogenase
9
PI-PLC
9
lecithin:cholesterol acyltransferase
9
NADH dehydrogenase
9
CD13
9
aspirin esterase
9
cellulase
8
more...
Compound
Dec
1980
water
1861
Clin
840
sodium
682
calcium
664
oxygen
604
DNA
591
ACh
591
glucose
511
phosphate
509
GSH
456
GSH
456
glutamate
406
hydrogen
390
galanthamine
376
acetate
355
nitric oxide
326
ethanol
315
serine
301
iodine
286
bromide
277
salt
268
potassium
262
PAM
260
nitrogen
252
methanol
252
sulfate
248
DPPH
239
silver
222
Physostigmine
222
copper
210
noradrenaline
208
Triton X-100
202
urea
201
ethyl acetate
199
GABA
195
GABA
191
ATP
185
5-HT
181
creatinine
172
zinc
171
Atropine
170
Chlorpyrifos
169
TNF
168
Tacrine
166
galactose
165
His
162
pyridine
159
ammonium
158
iron
150
phosphorus
142
tyrosine
142
arginine
142
DDVP
138
OMPA
130
cadmium
129
cysteine
125
NMDA
124
SDS
121
Rivastigmine
119
gamma-aminobutyric acid
117
cAMP
111
hexane
111
alanine
108
Soman
104
ACS
101
ACS
101
SEE
100
leucine
99
methionine
99
QNB
99
piperidine
97
piperidine
97
AMP
97
CAT
96
MDA
96
CAT
95
CAT
95
Pyridostigmine
94
aluminum
93
phenol
91
mercury
87
MTT
86
H2O2
86
nitrate
85
chloroform
85
Neostigmine
84
acetic acid
82
Neuronal
81
Asp
81
Formal
80
Gly
80
tryptophan
79
lysine
79
DEP
75
Mg2+
75
Memantine
74
nicotinamide
74
acrylamide
73
tryptophan
73
tryptophan
72
tryptophan
72
Choline
72
EDTA
71
Paraoxon
70
PAM
70
PAM
70
palmitic acid
70
Diazinon
70
Phe
69
EDTA
69
manganese
69
fluorine
68
DDT
68
selenium
68
dichloromethane
67
NADPH
66
NADPH
66
quinoline
65
quinoline
65
TMB-4
63
NH2
62
Pac
62
PEG
61
gallic acid
61
DAD
60
Sarin
59
4-nitrophenyl
59
retinoic acid
57
ammonia
56
Nicotine
56
NADH
54
benzene
54
glutamine
53
Panam
53
acetonitrile
52
acetone
52
caffeine
51
pyrene
51
DMSO
50
STZ
49
TOF
49
aspartic acid
48
formaldehyde
46
HCl
46
aldehyde
46
AMPA
45
proline
45
O,O-diethyl
45
Cereb
43
GPT
43
isoquinoline
43
Carbofuran
42
cobalt
42
Lead
42
nickel
41
CO2
41
glutamic acid
41
formaldehyde
41
GSSG
40
more...