Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.1.7 (acetylcholinesterase)
 28,390 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The intrinsic innervation of the kidney in Rattus rattus rufescens (Indian black rat) has been studied by cholinesterase technique, under various temperatures, incubation periods and different pH values. The percentage of myelinated nerves was rather high in the medulla region, whereas the non-myelinated nerves dominated in association with the uriniferous tubules and their branches, glomerulus and renal vein in the cortex region. Periarterial AChE-positive ganglia were recorded in the medulla region. The perivenous and periglomerulus plexuses were formed by the non-myelinated nerves and their branches.
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PMID:Neurohistological observations on the kidney of Rattus rattus rufescens (Indian black rat) as revealed by cholinesterase technique. 8 95

Presence and the relation of the nerve endings with associated structures in the lund of Rattus rattus rufescens (Indian black rat) and Francolinus pondicerianus (grey partridge or safed teeter) has been studied by cholinesterase technique. Dot, plate, and Vater pacini Corpuscles like nerve endings in the lung of Rattus and dot, and bulb like nerve endings with axis cylinder covered with myelinated sheath in the lung of Francolinus were recorded. The nerve endings were AChE-positive.
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PMID:Histochemical study on the nerve endings in the lung of Rattus rattus rufescens and Francolinus pondicerianus. 61 95

The present investigation was undertaken to study the innervation and acetylcholinesterase (AChE) distribution in the adrenal gland of Rattus rattus rufescens (Indian black rat) by cholinesterase technique. The percentage of myelinated nerves in the cortical zone (cortex) and medulla zone was high. AChE-positive and multipolar ganglia on the outer medulla region, and the ganglia and nerve cells, arranged in chain-like fashion in the chromaffin tissue, were recorded. AChE activity was marked in the cortical zone (in the form of spots) and in the medulla zone (in the form of white and black grains).
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PMID:Neuro-histochemical study of the adrenal gland of Rattus rattus rufescens (Indian black rat) as revealed by cholinesterase technique. 67 53

A survey was made of the density of the cholinergic innervation of different parts of the brainstem of the rat and ferret. Sections of rat and ferret brainstems were stained for choline acetyltransferase (ChAT) immunoreactivity by using a sensitive immunocytochemical method. Adjacent sections were stained for acetylcholinesterase activity or Nissl substance. The density of the distribution of fine calibre, varicose ChAT-positive axons, assumed to represent cholinergic terminals, was categorised arbitrarily into high, medium, or low. A high density of ChAT-positive terminals was found in all or parts of these structures: interpeduncular nucleus, superficial grey layer of the superior colliculus (ferret), intermediate layers of the superior colliculus, lateral part of the central grey (rat), an area medial to the parabigeminal nucleus (rat), pontine nuclei, ventral tegmental nucleus (rat), midline pontine reticular formation, and an area ventral to the exit point of the 5th nerve (ferret). A medium density of ChAT-positive terminals was observed in all or parts of: the substantia nigra zona compacta (ferret), ventral tegmental area (ferret), superficial grey layer of the superior colliculus, intermediate and deep layers of the superior colliculus, lateral central grey, area medial to the parabigeminal nucleus, inferior colliculus, dorsal tegmental nucleus, ventral tegmental nucleus (ferret), pontine nuclei, ventral nucleus of the lateral lemniscus (ferret), midline pontine reticular formation, ventral cochlear nucleus, dorsal cochlear nucleus, lateral superior olive, spinal trigeminal nuclei, prepositus hypoglossal nucleus, lateral reticular nucleus, paragigantocellular nucleus, and the dorsal column nuclei including the cuneate, external cuneate, and gracile nuclei. A low density of ChAT-positive terminals was seen throughout the remainder of the brainstem of the rat and ferret, but these terminals were absent from the medial superior olive, substantia nigra zona reticulata (rat), and the central part of the ferret lateral superior olive. A pericellular-like distribution of ChAT-positive terminals was observed in the ventral cochlear nucleus and in association with some of the cells of the nucleus of the mesencephalic tract of the trigeminal nerve. A climbing fibre type arrangement of ChAT-positive terminals was found in the substantia nigra zona compacta (ferret) and medial reticular formation. In general, the distribution of staining for AChE activity reflected that of the distribution of ChAT immunoreactivity in the brainstem, except in a few regions where there were also species differences in the distribution of ChAT-positive terminals, e.g., in the superficial grey layer of the superior colliculus and in the substantia nigra.(ABSTRACT TRUNCATED AT 400 WORDS)
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PMID:Distribution of choline acetyltransferase immunoreactive axons and terminals in the rat and ferret brainstem. 179 70

The putative cholinergic neurons of the basal forebrain and fibers in the hippocampus were studied in relation to galanin (GAL)-like immunoreactivity (LI) in the owl monkey by the use of acetylcholinesterase (AChE) histochemistry in combination with immunocytochemistry. Virtually all of the AChE-reactive somata within the medial septal nucleus, diagonal band and nucleus basalis and hippocampal AChE reactive fibers and varicosities co-contained GAL-LI. The more extensive distribution of GAL-like peptide in the cholinergic forebrain of the monkey (as compared to the rat) may reflect an increased importance of this peptide(s) in cotransmission processes in this region in higher animals.
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PMID:A galanin-like peptide coexists in putative cholinergic somata of the septum-basal forebrain complex and in acetylcholinesterase-containing fibers and varicosities within the hippocampus in the owl monkey (Aotus trivirgatus). 242 7

Factors which control the duration of postsynaptic responses in neuromuscular junctions are discussed together with a possibility of origin of trace postsynaptic reactions (potentiation and desensitization). In experiments on nerve-muscle preparations of various vertebrates (lamprey, frog, chicken, rat), the key role of functional activity of acetylcholinesterase was revealed in regulation of the duration of both short- and long-living postsynaptic responses. The significance of sufficient activity of acetylcholinesterase for normal realization of neuromuscular transmission presumably increases in the course of evolution of vertebrates. An analysis of possible molecular nature of trace reactions on the postsynaptic membrane was carried out.
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PMID:[Trace postsynaptic reactions in neuromuscular junctions]. 285 Dec 42

The distribution of the molecular forms of acetylcholinesterase in the blood of various animal species was examined. The globular tetrameric form was most frequently observed in serum but mouse serum also contained a globular monomer. Globular monomers (rat) dimers (mouse, dog, rabbit) and tetramers (dog) were found in erythrocytes. Interspecies differences make it difficult to formulate a cohesive theory as to the origin and function of blood-borne enzymes.
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PMID:Acetylcholinesterase molecular forms in serum and erythrocytes of laboratory animals. 285 47

An acetylcholinesterase (AChE) activity and a cholinesterase (ChE) activity were localized in mammalian kidneys, using a modified histochemical method of Koelle. The animals studied were mouse, hamster, cat, rat, and guinea pig. The kidneys were excised after in situ perfusion and fixation to eliminate AChE and ChE activities of blood. We carried out a relatively long incubation (up to 4 h) to detect weak AChE and ChE activities in the tissue. The differences in enzymatic activities in the kidneys from these 5 animals were important. The AChE activity was localized in the glomerulus (mouse, hamster, cat, and rat) and in the tubule (mouse, hamster, and rat). The ChE activity was also localized in the glomerulus (mouse and rat) and in the tubule (mouse and cat). An important nonspecific esterase activity was observed in the tubules of rat, guinea pig, and cat. In the thin segment of the loop of Henle, except of cat kidney, no esterase activity at all was observed. Electron microscopy revealed that, in the mouse kidney, both AChE and ChE activities were localized in the endoplasmic reticulum of glomerular endothelial cells and mesangial cells. (An AChE activity was localized mainly in mesangial cells, while ChE activity was localized mainly in endothelial cells). AChE and ChE activities were also localized in the endoplasmic reticulum of tubule cells.
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PMID:A histochemical localization of acetylcholinesterase and cholinesterase activities in mammalian kidneys. 309 Aug 31

Brain choline acetyltransferase, acetylcholinesterase with its molecular forms, and muscarinic receptor sites, as well as liver total cholinesterases were evaluated during the first postnatal month in pups of a precocial (Acomys cahirinus) and altricial (rat) murid species. At birth the levels of brain cholinergic markers were higher in the Acomys than in the rat, but in adulthood the differences were smaller or even reversed. The postnatal increase up in the markers to weaning was considerably more pronounced in the rat. However, substantial variations in the patterns of development of the three cholinergic markers within and between species were observed. Liver cholinesterases were considerably higher in Acomys than in rats at all ages investigated. These and literature data are discussed in relation to postnatal, post-conception and post-organogenesis age of pups belonging to the two species. The variability of the ontogenetic patterns between the enzymes suggests that there is some biological control of individual rates of maturation and that it is necessary to be careful in broadly interpreting growth patterns across organs within the same species and across species.
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PMID:Brain choline acetyltransferase and muscarinic receptor sites, brain and liver cholinesterases in precocial Acomys cahirinus and altricial rat during post-natal development. 325 18

Subcutaneous administration of 2 mg/kg cresylbenzodioxaphosphorin oxide (CBDP) produced complete inhibition of carboxylesterase activity in plasma and lung of mice, rats, guinea pigs and rabbits, without inhibition of acetylcholinesterase activity in either brain or diaphragm. This CBDP treatment also reduced the subcutaneous soman LD50 in these species by 48-90% in comparison to the soman LD50 in control animals. The interspecies differences in the soman LD50 values that were seen in control animals were absent in CBDP-treated animals. The soman LD50 values in control animals were 125 micrograms/kg (mouse), 116 micrograms/kg (rat), 32.3 micrograms/kg (guinea pig) and 22.8 micrograms/kg (rabbit), whereas the soman LD50 values in CBDP-treated animals from these species were clustered in a narrow dose range (11.8-15.6 micrograms/kg) and were not significantly different. This suggests that the amount of CBDP-sensitive carboxylesterase available for detoxification of soman in each species may be an important determinant of interspecies differences in soman toxicity.
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PMID:The effect of carboxylesterase inhibition on interspecies differences in soman toxicity. 367 54


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