Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.1.7 (acetylcholinesterase)
 28,390 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The influence of general anaesthesia for operations devoid of substantial tissue traumas on the postoperative pattern of hepatic enzymes was studied in 40 patients undergoing ophthalmologic surgery. 20 had neurolept analgesia, 20 had halothane anaesthesia. The duration of anaesthesia, age of the patients and their previous history corresponded fairly closely to those of a group of patients who had gynaecological operations and were the subject of a previous study. In contrast to the latter group total protein, cholinesterase, GOT, GPT, LDH, GLDH, AP, LAP and gamma-GT remained normal up to 12 days after the operation. The exception were changes in the total bilirubin levels which were similar to those observed in the gynaecological cases. Possible causes are discussed.
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PMID:[The effects of "atraumatic" surgery in halothane anaesthesia and neurolept analgesia on the liver enzyme pattern (author's transl)]. 4 96

In the present paper is reported on the behavior of different serochemical parameters in heterologous perfusion of the liver of pigs. The perfusion of the animal livers was carried out with preserved human blood in 11 recirculation experiments (closed machine circulations). In addition to this an empty circulation with human blood without attachment to an animal liver was carried out, whereby otherwise the arrangement of the experiment was the same, in order to take into consideration the effects of the blood traumatisation in the interpretation of the results. The enzymes GOT and LAP proved as sensible indicators of the lesion of the liver cells occurring in the perfusion of the liver of the pigs. The behavior of the mitochondrial GDH as well as of the lysosomal enzymes SP and BETA-GC which scarcely increased during the recirculations in the perfusate blood, however, allows the conclusion that there did not appear a severe lesion of the liver cells (necrobiosis) during several hours of perfusion. A cholestasis did not develop during the perfusions, when one takes as basis the behavior of the enzymes AP, GGTP and AAP indicating cholestasis. Compared with GOT the enzyme GPT showed by far less elevations in the perfusate blood so that with increasing duration of the perfusion the De-Ritis-quotient significantly increased. Increased LDH-activities above all revealed the increasing during perfusion haemolysis and less reliably a lesion of the liver of the pig. The increase of ADA in the perfusate blood proved as nearly exclusively conditioned by haemolysis. Total protein, albumins, immunoglobulins, cholinesterase and thymol turbidity test remained unchanged in the course of the perfusions.
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PMID:[Studies on the functional ability of swine liver perfused with human blood in machine recirculation attempt. 2. Behavior of serochemical parameters]. 96 Aug 62

A description is given of an outbreak of equine infectious anaemia (E.I.A.) in Campania [at Naples and Aversa (Caserta)]; it was diagnosed by clinical, pathological and serological examinations (Coggins test). Using the serum of 45 horses with E.I.A. and 11 healthy horses (controls), numerous investigations were carried out on: enzymes, intrinsic coagulation factors, lipids and other substances. The results obtained were very interesting and show that in this disease there are significant increases in many enzymes (LDH, LAP, gamma-GT, CPK, PK and ALD) and copper. Insignificant increases were found in other enzymes (SDH, GLDH, MDH, ICDH, AIP, lysozyme, cholinesterase, GOT and GPT) and also intrinsic coagulation factors, lipid substances (total cholesterol, esterified cholesterol, triglycerides) and glucose. LDH-1-isoenzyme remains unchanged, whilst AcP decreases slightly.
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PMID:Biochemical studies on equine infectious anaemia. 101 May 2

Nonvaccinated pigs were infected with a pathogenic virus of swine fever in order to follow up the changes with some enzymes in their blood serum. It was found that there is a dependable rise in the values of the blood serum GOT (2.6.1. 1.) - From about 38 to approximately 108 mU per cu. cm; GPT (2. 6; 1.2.;-From about 12 up to 66 mU/cu. cm; LAP (3. 4. 1. 1)-from about 13 to 27 mU/cu. cm; and ALD (4. 1; 2. 7.) - from about 6 up to 19 mU/cu. cm. These changes were noticed as early as the 48th hour of infection, prior to the manifestation of the clinical symptoms of swine fever. They remained stable up to the end of the infection process. The activity of LDH (1. 1. 2. 7.) and amylase (3. 2. 1.1 .) was said to rise (not dependable statistically), and that of cholinesterase (3. 1 1. 8) - to drop gradually with the development of the infection process. The two phosphomonoesterases (3. 1. 3. 1 and 3. 1. 3. 2.) showed no essential changes. The changes taking place in the activity of these enzymes did not depend on the extent of the hemorrhagic diathesis characteristic of swine fever. So, this test, which has been unknown so far, is referred to as a characteristic paraclinical symptom of swine fever.
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PMID:[Activity of several serum enzymes in swine with acute plague]. 117 33

Clinical usefulness of mean transit time (MTT) through the liver was evaluated by deconvolution analysis using 99mTc-EHIDA hepatobiliary scintigraphy in 82 patients with various hepatobiliary diseases and 18 normal controls. Initial transfer factor was also obtained according to the method of Rutland. Results obtained were as follows. 1) Effect of the age on MTT was not observed in normal controls. 2) MTT in left lobe of normal controls was significantly prolonged compared with that of right lobe (P less than 0.01). This kind of difference was not observed in patients with liver cirrhosis. 3) MTT in patients with obstructive jaundice, chronic liver diseases, liver cirrhosis at decompensative state and primary biliary cirrhosis was significantly prolonged compared with that in normal controls (P less than 0.01). 4) MTT in patients with liver cirrhosis at compensative state showed normal values, although blood clearance rate in those patients was significantly decreased (P less than 0.05). 5) Positive correlation was observed between MTT and values of T-Bil, ALP, LAP, and gamma-GTP. Negative correlation was observed between MTT and value of cholinesterase. 6) Initial transfer factor correlated with blood clearance rate. (r = 0.76, P less than 0.01). 7) Initial transfer factor in left lobe of normal controls was significantly decreased compared with that of right lobe (P less than 0.01). This kind of difference was not observed in patients with liver cirrhosis. 8) Initial transfer factor in patients with liver cirrhosis in both compensative and decompensative states and PBC was significantly decreased compared with that in normal controls. Estimation of MTT and initial transfer factor could be a useful parameters to assess transfer function of the liver.
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PMID:[Hepatic mean transit time of 99mTc-EHIDA estimated by deconvolution analysis]. 232 33

Clinical symptoms and abnormality of laboratory examinations in 62 patients with proven pancreatic carcinoma were studied. The following indications for detailed examination of the pancreas have been evolved: (1) vague abdominal symptoms, (2) jaundice, (3) abnormalities of laporatory examinations including serum LAP, ALP, amylase and cholinesterase level, and abnormal GTT. In the jaundiced patient the initial examination is US followed by PTCD to relieve the jaundice, and then angiography to assess resectability of the tumor. In the non-jaundiced patient US is used as a screening procedure. Should this be abnormal a lesion may be confirmed by CT. If not ERCP is indicated when there is some distinct reason to suspect pancreatic disease. If ERCP reveals abnormality then angiography is performed to determine whether the lesion is benign or malignant, and if malignant it is resectable or not. In the period of 1968 and 1981, 112 proven pancreatic carcinomas were studied. Overall resectability was 26%. Thirty tumors were less than 3 cm and the smallest lesion measured 1.2 cm.
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PMID:[Problems of early diagnosis of pancreatic cancer and evaluation of various morphological studies]. 687 17