Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.7 (
acetylcholinesterase
)
28,390
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Presenilin 1
(
PS1
) plays a critical role in the gamma-secretase processing of the amyloid precursor protein to generate the beta-amyloid peptide, which accumulates in plaques in the pathogenesis of Alzheimer's disease (AD). Mutations in
PS1
cause early onset AD, and proteins that interact with
PS1
are of major functional importance. We report here the coimmunoprecipitation of
PS1
and
acetylcholinesterase
(
AChE
), an enzyme associated with amyloid plaques. Binding occurs through
PS1
N-terminal fragment independent of the peripheral binding site of
AChE
. Subcellular colocalization of
PS1
and
AChE
in cultured cells and coexpression patterns of
PS1
and
AChE
in brain sections from controls and subjects with sporadic or familial AD indicated that
PS1
and
AChE
are located in the same intracellular compartments, including the perinuclear compartments. A
PS1
-A246E pathogenic mutation expressed in transgenic mice leads to decreased
AChE
activity and alteration of
AChE
glycosylation and the peripheral binding site, which may reflect a shift in protein conformation and disturbed
AChE
maturation. In both the transgenic mice and humans, mutant
PS1
impairs coimmunoprecipitation with
AChE
. The results indicate that
PS1
can interact with
AChE
and influence its expression, supporting the notion of cholinergic-amyloid interrelationships.
...
PMID:Presenilin 1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation. 1829 93
