Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.7 (acetylcholinesterase)
 28,390 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Parathion-methyl, 10 mg/kg p.o., was given to unexercised rats, rats trained for 3 weeks and resting for 2 days, and trained rats subjected to a single physical exercise before treatment. The activity of cholinesterase (ChE) in the serum, of paraoxonase--in the serum and liver, and of beta-glucuronidase (beta-gluc)--in the serum, liver and intestine were determined 1 h after the treatment. Repeated physical exercise increased beta-gluc activity in the serum and liver and inhibited it in the intestine, while a single race after repeated exercise inhibited paraoxonase activity in the serum. Parathion-methyl inhibited ChE and paraoxonase activities and an increased beta-gluc activity in the serum. Repeated physical exercise and a single race, applied 2 days after the end of training, affects the activity of parathion-methyl in a significant yet diversified manner, dependent upon the examined biochemical parameters.
Pol J Pharmacol Pharm
PMID:The effect of chronic physical exercise on the activity of hydrolytic enzymes in acute poisoning with parathion-methyl in rats. 300 32

This study was aimed to examine whether disulfiram (DS) may exacerbate the pre-existing liver damage induced by D-galactosamine (GalN) in rats. DS, 600 mg/kg, administered by gavage for 3 days caused an increase in asparagine aminotransferase (AspAT) and alkaline phosphatase (AP) and a decrease in cholinesterase (ChE) activity in the serum and decrease in AspAT and ChE activity in the liver. DS given to rats with GAlN-induced liver injury caused significant increase in alanine aminotransferase (A1AT) and bilirubin level in serum in comparison with rats with GalN-damaged liver but without DS treatment. In summary, DS exacerbates a damage of the liver of rats. This study supported the clinical observations showing enhanced liver damage in alcoholics treated with DS.
Pol J Pharmacol Pharm
PMID:Effect of disulfiram on function of the liver of rats with galactosamine-induced hepatitis. 309 1

The authors report three cases of poisoning with organic phosphate compounds in children. The first case presented a complex of late signs in the form of toxic polyneuropathy, and two had an acute course. The observation confirmed the view that an at least 7-day hospital stay and 4-week follow-up are necessary in view of great fluctuations in the level of cholinesterase which is often not correlated with the clinical status.
Neurol Neurochir Pol
PMID:[Neurologic complications in organophosphate insecticide poisoning in children]. 314 6

Brain choline acetyltransferase, acetylcholinesterase with its molecular forms, and muscarinic receptor sites, as well as liver total cholinesterases were evaluated during the first postnatal month in pups of a precocial (Acomys cahirinus) and altricial (rat) murid species. At birth the levels of brain cholinergic markers were higher in the Acomys than in the rat, but in adulthood the differences were smaller or even reversed. The postnatal increase up in the markers to weaning was considerably more pronounced in the rat. However, substantial variations in the patterns of development of the three cholinergic markers within and between species were observed. Liver cholinesterases were considerably higher in Acomys than in rats at all ages investigated. These and literature data are discussed in relation to postnatal, post-conception and post-organogenesis age of pups belonging to the two species. The variability of the ontogenetic patterns between the enzymes suggests that there is some biological control of individual rates of maturation and that it is necessary to be careful in broadly interpreting growth patterns across organs within the same species and across species.
Pol J Pharmacol Pharm
PMID:Brain choline acetyltransferase and muscarinic receptor sites, brain and liver cholinesterases in precocial Acomys cahirinus and altricial rat during post-natal development. 325 18

After local administration into the midbrain reticular formation of an acetylcholinesterase reactivator--Pralidoxime, a significant decrease of intensity of hippocampal theta rhythm induced by previous inhibition of acetylcholinesterase by DFP was observed already after 10 min. This result suggests that cholinergic structures are localized in midbrain reticular formation and that they play a role in the origin of hippocampal theta rhythm.
Acta Physiol Pol
PMID:Effects of pralidoxime applied locally into the midbrain reticular formation on the hippocampal theta rhythm induced by acetylcholinesterase inhibition. 342 Nov 36

The studies were carried out in vitro on the jejunum of 10 pigs, 10 rabbits and 10 guinea pigs. The activity monoaminooxidase (MAO) was determined manometrically in Warburg's apparatus, that of acetylcholinesterase (AChE) spectrophotometrically after Ellman's method modified by urek and Syrowatka. The obtained results were statistically analysed. It was shown that in the animals studied the bile acids exerted a considerable effect on the activity of enzymes metabolising neurohormones. Under the influence of bile the activity of monoaminooxidase was inhibited. Stimulating, but less distinctly, bile effected the activity of acetylocholinesterase. Significant differences in the action of bile on the activity of these enzymes were found in the jejunum of the animal species studied. The highest decrease in the activity of MAO under the influence of bile was found in the jejunum of the rabbit (by about 65%), a weker in the pig (by 37.5%) and guinea-pig (by 18.5%). However, the highest increase in the activity of AChE under the influence of bile occurred in the pigs (by about 21.6%), a weaker in the rabbit (by 16.4%) and guinea-pig (by about 11.5%). Among the bile acids, the strongest action on both the activity of MAO and AChE was exerted by lithocholic acid, desoxycholic, weaker by cholic and chenodesoxycholic acid. MAO activity under the influence of lithocholic acid decreased (in the pig by about 63%, rabbit by 55.7% and guinea pig by 34.8%). After incubation of the jejunum in desoxycholic acid a decrease in MAO activity occurred (in the rabbit by 43.8%, pig by about 39.4% and guinea-pig by 15.7%). AChE activity under the influence of lithocholic acid increased (in the pig on average by 62.2% rabbit by 21.8 and guinea-pig by about 10.2%). After incubation of the jejunum in desoxycholic acid an increase in the activity of acetylcholinesteras occurred (in the pig by about 13.5%, guinea-pig by 7.7% rabbit 7.3%).
Pol Arch Weter 1987
PMID:[Effect of bile and bile acids on monoamine oxidase and acetylcholinesterase activity in the jejunum of rabbits, guinea pigs and swine]. 369 37

The reported experiments were carried out on male Wistar rats. Under general anaesthesia with chloral hydrate in situ physiological preparations were made consisting of sciatic nerve and anterior tibialis muscle. Physostigmine was injected subcutaneously and was followed after from 15 to 60 minutes by intravenous injection of DDVP or phospholine. Physostigmine effect on the blockade of tetanic muscular contractions was studied after administration of these organophosphate inhibitors of acetylcholinesterase. At the same time, the effect of these substances on acetylcholinesterase was determined in the skeletal muscle. It was found that physostigmine in a dose of 125 microgram/kg protected the tibialis muscle against the development of blockade of tetanic response. The protective effect was greatest when the time between physostogmine injection and the subsequent administration of these organophosphate inhibitors was 30--40 minutes. In the same observation period the activity of AChE in the tibialis muscle of rats was found to be highest after physostigmine injection before administration of DDVP or phospholine.
Acta Physiol Pol
PMID:Effect of preceding physostigmine administration on neuromuscular transmission disturbances in rats caused by dichlorphos and phospholine. 625 49

In an isolated preparation of rat diaphragm stimulated indirectly (12 impulses per minute) after total inactivation of acetylcholinesterase phospholine reduced the amplitude of the response proportional to its concentration. The rise in the concentration of potassium, magnesium or calcium in the incubation fluid failed to alleviate the disturbances produced by phospholine. Phospholine increased significantly reduction of response amplitude caused by increased calcium and magnesium concentration and increased to a small extent response depression caused by raised potassium concentration. The obtained results, point out that phospholine exerts a direction on the neuromuscular junction which is connected with the postsynaptic action of this agent.
Acta Physiol Pol
PMID:The effect of certain electrolytes on neuromuscular transmission disturbances evoked by direct action of phospholine on synaptic structures. 626 79

The activity of acetylcholinesterase was determined in the skeletal muscle and brain of rats after one exercise (running) and after long-term training of definite programme. Enzyme activity was determined by the colorimetric method of Hestrin. The results were subjected to statistical analysis by the t test of Student. An increase was demonstrated in AChE activity after one exercise in both tissues, but only in the muscle this increase was statistically significant. After long-term training the direction of this change was reversed. In the muscle the decrease was statistically significant, while the change in the brain was not significant.
Acta Physiol Pol
PMID:Acetylcholinesterase (E.C.3.1.1.7) in the skeletal muscle and brain of rats after exercise and long-term training. 654 88

Intracerebroventricular injection of glycine elevated the level and synthesis rate of acetylcholine and the activity of choline acetyltransferase in the striatum. Administration of strychnine alone did not change these parameters, but pretreatment with strychnine abolished the stimulatory effect of glycine on the cholinergic system of the rat striatum. Separate or combined administration of strychnine and glycine did not affect the striatal acetylcholinesterase activity. The drugs did not produce any changes in the cholinergic system indices in the hippocampus.
Pol J Pharmacol Pharm 1983
PMID:The influence of strychnine and glycine on the metabolism of acetylcholine in the rat striatum and hippocampus. 666 34


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