Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.7 (
acetylcholinesterase
)
28,390
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In this study, a mammalian expression vector containing cDNA of human GAP (
p120GAP
) or its deletion mutant was transfected into PC12 cells. The deletion mutant peptide has SH2 and SH3 domains, but no GTPase activating domain. Cells stably overexpressing intact
p120GAP
showed enhanced proliferation, demonstrated by 5-bromo-2'-deoxyuridine labeling and cell cycle analysis. On the other hand, in cells expressing the deletion mutant GAP, differentiation induced by NGF was potentiated, as demonstrated by enhanced
acetylcholinesterase
activity and induction of neurofilament proteins.
...
PMID:Proliferation and differentiation of PC12 cells were affected by p21ras GTPase activating proteins and its deletion mutant proteins. 856 92
