Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.7 (
acetylcholinesterase
)
28,390
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Diethyl phosphate
(
DEP
), an organophosphate metabolite, was found in the urine of symptomatic residents who resided in a household that had been sprayed with diazinon 4.5 mo earlier. Pre- and post-decontamination data with regard to symptoms,
DEP
,
cholinesterase
, and surface and air levels underscore the utility of alkyl phosphate metabolites for monitoring exposure. The data also emphasize the efficacy of clean-up measures when baseline data are not available to determine if "within-normal"
cholinesterase
levels are, in fact, depressed.
...
PMID:Illness and excretion of organophosphate metabolites four months after household pest extermination. 156 37
1. The metabolism of the phosphorothionate parathion in vitro was examined by using [(32)P]parathion and microsomes isolated from the livers of various animal species. 2. The major metabolic products of parathion in this system in vitro were identified as diethyl 4-nitrophenyl phosphate (paraoxon),
diethyl hydrogen phosphate
, diethyl hydrogen phosphorothionate and p-nitrophenol. 3. The reaction leading to the formation of diethyl hydrogen phosphorothionate and p-nitrophenol requires the same cofactors (NADPH and oxygen) required for metabolism of parathion to its active anti-
acetylcholinesterase
paraoxon. 4. The enzyme activity towards parathion per unit weight of liver is increased some 65-130% by pretreatment of male rats with phenobarbital and 3,4-benzopyrene. 5. The metabolism of parathion is inhibited by incubation in a nitrogen atmosphere and in an atmosphere containing carbon monoxide. Pure oxygen is also inhibitory. These results are discussed in terms of a deficiency of oxygen for maximal activity as well as the lability of some component of the system to oxidation.
...
PMID:Studies on the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) in vitro. 438 89
