Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:3.1.1.7 (acetylcholinesterase)
 28,390 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The haematological and hepatotoxic effects were studied after oral administration of Isoprocarb at 75, 112.5 and 150 mg kg-1 daily for 21 days in male and female chicken Gallus gallus domesticus (White Leghorns). The toxic effects as observed 10 or 21 days after medication include a statistically significant reduction in haemoglobin (Hb) content, haematocrit (Ht), protein and serum glutamate pyruvate transaminase (SGPT), and an increase in glucose, serum glutamate oxaloacetate transaminase (SGOT) and serum acid phosphatase (SAP) activities of male and female chicken. The changes in other haematological parameters were generally insignificant, except for one or two doses in RBC, WBC, mean corpuscular haemoglobin concentration (MCHC) and chloride. A significant inhibition of RBC acetylcholinesterase was noticed after 21 days of dosing only at the high dose (150 mg kg-1) in hens. The decrease in food intake and body weights of males and females indicated the overt signs of toxicity. In addition to haematological alterations, the results suggest both hepatotoxic and stress effects and pinpoint that these early biochemical changes induced by Isoprocarb may be predictive of pesticide toxicity.
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PMID:Haematological and hepatotoxic effects of isoprocarb in chicken. 238 Apr 80

This study was undertaken to investigate the possibility that non-cholinergic mechanism accounts for acute lethality of cholinesterase (ChE) inhibitor. Physostigmine and carbamate insecticides (2-s-butylphenyl methylcarbamate (BPMC); isoprocarb, 2-isopropylphenyl methylcarbamate (MIPC); and propoxur, 2-isopropoxyphenyl methylcarbamate (PHC)) were employed as ChE inhibitors. Rabbits intravenously given any of the ChE inhibitors showed typical signs of anti-ChE poisoning, a marked inhibition of systemic ChE activity, and an increase in RR interval on an ECG. Injection of physostigmine or PHC at a lethal dose produced a pressor response before cessation of spontaneous breathing. In contrast, injection of MIPC or BPMC primarily elicited a cardiovascular collapse, characterized by a rapid and progressive decrease in blood pressure and a decrease in QRS amplitude of ECG, before cessation of spontaneous breathing. The atropine pretreatment inhibited the pressor response, but not the depressor response and the QRS change. The pretreatment antagonized acute lethality of the ChE inhibitors except BPMC. It is suggested that the mode of lethality for intravenous ChE inhibitor could be determined by a balance between anti-ChE activity and some mechanism other than ChE inhibition. BPMC produced acute lethality through the latter mechanism rather than the former one.
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PMID:Non-cholinergic lethality following intravenous injection of carbamate insecticide in rabbits. 797 14

Investigations were undertaken to monitor the health status of farm labourers engaged in field sprays of MIPC 50 WP (Hexamicin, Mipcin), a carbamate insecticide on cotton crop, as per the protocol approved by the Central Insecticide Board The insecticide sprays (0.1%) were undertaken for six hr on three consecutive days on 1.2 hectares of cotton crop per day, using Aspee napsak sprayers. The spray personnel (mixers, loaders and sprayers) with protective clothing did not reveal any alteration in clinical, hematological and blood bio-chemical profile during exposure and post exposure periods. The spray personnel without protective clothing showed only a marginal reduction in their blood cholinesterase activity during the exposure period.
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PMID:Health monitoring of farm labourers engaged in MIPC 50 WP field sprays. 1297 65