Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.7 (
acetylcholinesterase
)
28,390
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A hybrid cell line (
E-2
) that secretes the enzyme
acetylcholinesterase
(
AChE
) has been prepared. The
E-2
cell was the product of a fusion between primary mouse hepatocytes and a chemically transformed rat liver cell line (FRL), neither of which expresses
AChE
activity. The enzyme was determined to be
AChE
on the basis of its susceptibility to inhibition by BW284c51 but not by iso-OMPA, as well as its substrate specificity. Although the secreted enzyme was salt soluble and its activity not modified by the addition of the nonionic detergent, Triton X-100, the activity of the cellular enzyme (derived from homogenates of
E-2
cells) was greatly enhanced in the presence of the detergent.
...
PMID:Secretion of acetylcholinesterase by a mouse hepatocyte X rat liver cell hybrid culture. 349 Oct 63
