Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.7 (
acetylcholinesterase
)
28,390
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Thirty-eight 7-week-old white leghorn chickens of two strains (high and low antibody response to sheep erythrocytes) were divided into groups for exposure to high and low levels of
social stress
. They were then challenged orally with a toxic dose of the organophosphate insecticide malathion (250 mg/kg body weight) and evaluated 60 min later for muscarinic signs (diarrhea, lacrimation, respiratory secretions), nicotinic signs (muscle weakness), plasma
cholinesterase
activity, and brain
acetylcholinesterase
activity. A significant correlation was shown between clinical and biochemical indices of organophosphate toxicity. The correlation between
social stress
and malathion toxicity was less well defined. Chickens with low antibody response preexposed to high
social stress
were most resistant to organophosphate toxicity.
...
PMID:Effects of social stress on the toxicity of malathion in young chickens. 381 4
Chickens housed for 4.5 months in an environment of either low
social stress
or high
social stress
were administered triorthotolyl phosphate (TOTP) 180 mg/kg po. Clinical signs of delayed neuropathy were less in the low
social stress
group, unless moved to a high stress environment 24 hr before TOTP administration. Neurotoxic esterase activity was less than 20% of control values in all treatment groups. Birds from the low
social stress
group moved 24 hr prior to TOTP were more susceptible to inhibition of brain and liver
cholinesterase
activities following organophosphate administration. Liver microsomal enzyme activities (O-demethylase and aniline hydroxylase) were lowest in unmoved low
social stress
birds after TOTP, possibly protecting these birds from delayed neuropathy by reducing conversion of this organophosphate to its active metabolite.
...
PMID:Modification of triorthotolyl phosphate toxicity in chickens by stress. 662 67
