Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.7 (
acetylcholinesterase
)
28,390
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Patients with
guttate psoriasis
have been reported to respond to anticholinergic treatment. We wanted to know how the cholinergic system could be involved in this process. Mast cells are characteristic components of the inflammatory infiltrate of
guttate psoriasis
. We therefore studied the cholinergic system in both epidermis and mast cells of 10 patients with
guttate psoriasis
in involved and uninvolved skin on protein level using immunofluorescence and in a mast cell line (HMC-1) using PCR. Both in vivo and in vitro, mast cells lacked expression of cholinacetyl transferase, vesicular acetylcholine transporter and choline transporter-1 but contained high levels of
acetylcholinesterase
and different nicotinic and muscarinic acetylcholine receptor (AChR). In lesional epidermis, both acetylcholine production and AChR expression was mostly shifted from the basal to the suprabasal layers. In vitro, acetylcholine, choline and nicotine, but not muscarine, induced mast cell degranulation but not LTB-4 or TNF-alpha secretion. This process could be inhibited by low doses of different nicotinic acetylcholine receptor antagonists.
...
PMID:The cholinergic system in guttate psoriasis with special reference to mast cells. 2152 72
