Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.7 (
acetylcholinesterase
)
28,390
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We here report observations on the distribution of
acetylcholinesterase
(
acetylcholine hydrolase
,
EC 3.1.1.7
) in the striatum of the adult human, the rhesus monkey, and the cat. By the histochemical staining methods of Geneser-
Jensen
and Blackstad and of Karnovsky and Roots, compartments of low
cholinesterase
activity were identified in parts of the striatum in all three species. In frontal sections, these enzyme-poor zones appeared as a variable number of weakly stained approximately 0.5-mm-wide zones embedded in a darkly stained background. The zones varied in cross-sectional shape from round to elongated and were sometimes branched. They were most prominent in the head of the caudate nucleus. Three-dimensional reconstructions of serial sections through the caudate nucleus in the human and cat suggest that over distances of at least several millimeters, the zones of low enzyme activity form nearly continuous labyrinths.
...
PMID:Histochemically distinct compartments in the striatum of human, monkeys, and cat demonstrated by acetylthiocholinesterase staining. 10 1
The distribution of
acetylcholinesterase
(
AChE
) was explored in the striatum of the cat following a slightly modified Geneser-
Jensen
and Blackstad method. The well-known histochemical organization of the cat's striatum, characterized by the presence of small areas with poor concentration of
AChE
, called "striosomal bodies" or "striosomes", which were embedded in a prominent tissular matrix presenting more intense staining for
AChE
, was clearly recognized. An additional finding, however, was that regional variations in the deposit of
AChE
both in the striosomal bodies and in the matrix-compartment, occurred within different rostrocaudal and dorsoventral striatal territories of the cat's caudate nucleus. These results point to consider these two striatal compartments as part of a more complex histochemical design for the striatum of carnivores.
...
PMID:Histochemical assessment upon the striatal distribution of acetylcholinesterase in the cat. 848 Oct 85
