Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.7 (
acetylcholinesterase
)
28,390
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Blood samples from 580 African
leprosy
patients living in Rhodesia have been phenotyped for the plasma
cholinesterase
variants. The Africans have been grouped according to country of origin and tribal affiliation. We have found no individual with an Ea1 gene and are unable to resolve the contradictory evidence for an association between this gene and
leprosy
. The frequency of the Ef1 gene is higher than that usually found in Caucasian populations, being 0.046 in lepromatous
leprosy
patients and similar to the 0.056 found in healthy African controls. In tuberculoid
leprosy
patients the frequency is, however, significantly lower at 0.019. On the other hand, the frequency of the C5+ variant is essentially the same for the tuberculoid
leprosy
patients and the healthy controls (4%) while for the lepromatous
leprosy
patients it is about 7% approaching the 10-15% found in many Caucasian populations.
...
PMID:Serum cholinesterase variants in African leprosy patients resident in Rhodesia. 99 65
An inhibition of
acetylcholinesterase
activity by ranitidine and cimetidine as described by
Hansen
and Bertl (Z. Gastroenterol. 21: 164, 1983; Arzneimittelforsch. 33: 161, 1983) could only be confirmed by use of 1000-fold higher concentrations of the H2-antagonists (ID50 for ranitidine: 3,2 X 10(-4) M, for cimetidine: 3,1 X 10(-2) M) than those reported by the authors. The discrepancy may be explained by the fact that the authors did not consider the dilution factor in their method. In a typical therapeutic situation in 8 patients with ranitidine 150 mg twice daily and cimetidine 400 mg twice daily an inhibiton of the
acetylcholinesterase
could not be demonstrated. The inhibition of the
acetylcholinesterase
activity by H2-antagonists is of no practical relevance.
...
PMID:[Relevant inhibition of acetylcholinesterase with H2-receptor antagonists]. 632
