Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.7 (
acetylcholinesterase
)
28,390
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Two substrates, acetyl thiocholine iodide ATCI and benzoylcholine chloride
BCC
were compared for the determination of plasma
cholinesterase
ChE levels and after incorporation of dibucaine and sodium fluoride in the assay, their usefulness in determining plasma ChE genetic variability was assessed in 64 healthy subjects. With both substrates, plasma ChE levels were found to be in the reference range. However, ATCI could detect only two variants with the usual phenotype UU in 60 of 64 [93.75%] subjects whereas with
BCC
6 different groups could be determined. Though both substrates are of equal value in estimation of plasma ChE levels,
BCC
is definitely superior in determining its genetic variants.
...
PMID:Comparison of two substrates in determination of plasma cholinesterase activity & genetic variability. 884 Jun 60
