Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.53 (sialidase)
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Human Gene/Protein
NEU3 protein 13.5
sialidase 13.5
NEU3 13.1
ganglioside sialidase 13.0
Sialidase 13.0
NANH 12.9
lysosomal sialidase 12.9
NEU4 12.9
NEU2 12.8
exo-alpha-sialidase 12.5
NEU1 protein 12.5
cytidine monophosphate N-acetylneuraminic acid synthetase 12.5
sialyltransferase 4C 12.5
NEU1 12.2
ST8SIA3 11.9
neuraminidase 4 11.9
Chemokine (C-C motif) ligand 19 11.5
MUB 11.4
CASD1 11.2
sialyltransferase 6 10.9
HYALP1 10.9
beta-galactoside alpha-2,6-sialyltransferase 10.9
N-acetylneuraminate lyase 10.8
alpha2,3-sialyltransferase 10.6
ST8Sia III 10.6
cathepsin A 10.6
Nicalin 10.5
MPS7 10.5
alpha2,8-sialyltransferase 10.4
PPGB 10.4
SLG2 10.2
Kallikrein-related peptidase 4 10.2
HYAL4 10.1
ST3N 10.1
AMAC 10.1
SIGLEC5 10.1
alpha-N-acetylgalactosaminidase 10.0
ST6GalNAc III 9.9
neuraminidase 3 9.9
alpha 2,6-sialyltransferase 9.9
Siglec-5 9.7
sialic acid synthase 9.7
Deoxyribonuclease II 9.6
ATAD1 9.5
sialyltransferase 9.5
GD3S 9.4
O-sialoglycoprotein endopeptidase 9.4
TES1 9.3
Siglec-1 9.2
HYAL3 9.2
Siglec-14 9.2
N-acetylglucosamine-6-phosphate deacetylase 9.1
ST3GAL3 9.1
ST6Gal I 9.1
ST8SIA2 9.1
sphingolipid activator proteins 9.1
GM2 activator protein 9.1
ST8Sia II 9.0
striatum-enriched 9.0
AP-B 9.0
sialomucin 9.0
CMP-sialic acid transporter 8.9
Siglec-15 8.9
GD3 synthase 8.9
ST3Gal II 8.9
metastasis-related protein 8.9
mucin MUC5B 8.9
ST6GalNAc I 8.9
CHST1 8.9
sarcolectin 8.9
HCA1 8.8
alpha2,6-sialyltransferase 8.8
alpha 2,3-sialyltransferase 8.8
ST8Sia IV 8.8
prokineticin receptor 2 8.8
A1BG 8.7
FUT9 8.7
ST6GALNAC2 8.7
SCR3 8.7
Siglec-8 8.7
more...
Disease
sialidosis 11.4
SGM1 11.2
adult GM1 gangliosidosis 10.9
Galactosialidosis 10.6
ORM1*F1 10.1
Chronic Chagas' disease 9.8
ORM1*S 9.7
sialic acid storage disease 9.5
AKE 9.3
MPS IIID 9.0
HCA1 8.8
Salla disease 8.7
nagana 8.2
AB variant 8.1
Gardnerella 8.1
Mucolipidosis type IV 8.0
Thomsen 8.0
GM1 gangliosidosis 7.9
Chagas 7.9
lipoprotein disorder 7.9
clostridial infection 7.8
bacterial vaginosis 7.8
SBL 7.8
gas gangrene 7.7
RHS 7.7
Imerslund 7.7
Sandhoff disease 7.4
Infection induced 7.4
gangliosidosis 7.3
LINCL 7.3
Parainfluenza 7.3
Influenza A virus infection 7.3
vaginosis 7.2
Infantile neuronal ceroid lipofuscinosis 7.0
Diaz 6.8
Kufs' disease 6.8
atrophic vaginitis 6.7
Hurler 6.7
Collet-Sicard syndrome 6.6
PLAT 6.5
LAD2 6.5
lysosomal storage disease 6.4
Tay-Sachs disease 6.3
vaginal infection 6.3
Schmitz 6.3
Morquio 6.3
MNS 6.2
Newcastle disease 6.2
cholera 6.1
WSN 6.1
WSN 6.1
mannosidosis 5.9
ISH 5.9
fucosidosis 5.8
Scheie 5.7
stomatocytosis 5.7
acrocyanosis 5.7
GM2 gangliosidosis 5.7
influenza 5.5
primary disorders 5.5
lung consolidation 5.5
leukemoid reaction 5.5
progressive muscular atrophy 5.4
angiokeratoma 5.3
African trypanosomiasis 5.3
funnel chest 5.2
DBA 5.2
avian influenza 5.2
trypanosomiasis 5.2
Immune thrombocytopenia 5.2
spondyloepiphyseal dysplasia 5.2
LCA 5.2
ST8 5.1
human granulocytic ehrlichiosis 5.1
protein deficiency 5.1
myoclonus epilepsy 5.1
urticaria pigmentosa 5.0
epididymo-orchitis 5.0
Ovary 5.0
swine influenza 5.0
more...
Symptom
Mucosal hyperplasia 9.3
myoclonus 5.6
hepatosplenomegaly 4.6
ataxic gait 4.4
cerebellar ataxia 4.0
clonus 4.0
rigors 3.8
livedo 3.8
dysarthria 2.6
blurred vision 2.5
ataxia 2.4
paraparesis 2.1
hypotonia 2.0
HSA 2.0
acidity 2.0
spasticity 1.9
functional recovery 1.8
acute stress 1.4
diarrhea 1.3
hepatomegaly 1.0
exhaustion 0.8
dystonia 0.5
seizures 0.4
tremor 0.4
weakness 0.3
splenomegaly 0.3
thinning 0.1
dyspnea -0.2
respiratory distress -0.7
fatigue -2.1
pain -2.9
Drug
Ches 9.8
Relenza 9.5
Diphtheria antitoxin 8.7
Myozyme 8.7
Oseltamivir 8.5
GNA 8.0
Epoetin beta 7.9
Pancreatin 7.7
Ganciclovir 6.6
Pertuzumab 6.5
Darbepoetin alfa 6.2
K-252a 6.1
Galactose 6.1
NAG 6.0
lactose 6.0
Pronase 6.0
Spiegel 5.7
Cibacron Blue 5.6
Sodium alginate 5.6
Lovastatin 5.5
Epoetin 5.5
Bifidobacterium 5.3
anti-CD33 5.1
Indapamide 5.1
AraC 5.1
Gel 4.8
MTC 4.5
Papain 4.4
Lactose 4.4
linolenate 4.3
ABC 4.2
Kainic acid 4.2
HCH 4.1
Erlotinib 4.0
DEX 3.7
Asn 3.5
Hypaque 3.4
Hypaque 3.3
CaCl2 3.2
CaCl2 3.2
CaCl2 3.2
BH4 3.0
PTC 2.8
CAM 2.6
Paraffin 2.4
Fragment 2.3
IFN-gamma 2.3
Fraction 2.2
Alanine 2.1
Ringer's solution 2.1
IL-2 1.9
Ethanol 1.9
MRC 1.8
Kenyan 1.8
THF 1.5
nitroglycerin 1.4
Adriamycin 1.3
Albumin 1.3
lysine 1.3
Glutathione 1.1
NADH 1.1
Histamine 1.1
CTX 1.1
CTX 1.0
Leaf 0.7
EE2 0.6
MAP 0.6
DNase I 0.5
ENT 0.5
CTX 0.2
CSF 0.2
ROS -0.7
caffeine -0.9
Dermatol -1.7
Enzyme
sialidase 13.5
sialidase L 13.5
mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase 12.5
sialate O-acetyltransferase 12.2
aminopeptidase Ey 11.9
sialate O-acetyltransferase 11.2
CMP-sialic acid hydrolase 11.2
NeuAc synthase 11.1
neuraminidase 11.1
glycosulfatase 10.8
globoside synthase 10.5
endo-alpha-N-acetylgalactosaminidase 10.5
lacto-N-biosidase 10.4
alpha-N-acetylgalactosaminidase 10.1
acetylesterase 10.0
endoglycoceramidase 9.8
EC 2.4.99.4 9.6
EC 3.2.1.99 9.5
endo-beta-galactosidase 9.5
sialyltransferase 9.5
sialyltransferase 9.5
sialyltransferase 9.5
glycoprotease 9.4
endo-beta-galactosidase 9.2
EC 2.4.99.1 9.1
N-acetylglucosamine-6-phosphate deacetylase 9.1
N-acetylgalactosaminidase 9.0
galactose oxidase 8.7
NPL 8.6
cruzipain 8.6
GD3 synthase 8.6
phosphatidylinositol phospholipase C 8.5
alpha-L-fucosidase 8.5
glucosamine-6-phosphate deaminase 8.4
alpha-galactosyltransferase 8.2
carboxypeptidase Y 8.2
N-acetylmannosamine kinase 8.2
CMP-Neu5Ac hydroxylase 8.0
PNGase F 7.8
alpha-L-rhamnosidase 7.7
CMP-Neu5Ac synthetase 7.7
hexosaminidase 7.7
clostripain 7.6
hyaluronate lyase 7.6
beta-D-fucosidase 7.5
GM3 synthase 7.4
alpha-L-fucosidase 7.4
alpha-L-fucosidase 7.3
arabinosidase 7.3
GPI-specific phospholipase C 7.2
heparitinase I 7.1
UDP-galactopyranose mutase 7.0
chondroitinase AC 6.8
beta-galactosidase 6.8
alpha-mannosidase 6.8
bromelin 6.7
endo-N 6.6
chondroitinase 6.6
alpha-galactosidase 6.6
oligopeptidase B 6.5
chondroitinase 6.4
PI-PLC 6.4
arylsulfatase A 6.3
glucosylceramide synthase 6.2
prolidase 6.2
endoglycosidase H 6.2
ceramidase 6.1
N-acetylglucosaminyltransferase 6.1
trypanothione reductase 6.1
beta-glucosidase 6.1
chondroitin ABC lyase 6.0
glucosidase II 6.0
beta-glucosidase 5.9
N-acetylglucosaminyltransferase I 5.9
galactocerebrosidase 5.8
hyaluronidase 5.8
aminopeptidase A 5.8
endoproteinase Glu-C 5.8
uridyltransferase 5.8
sulfatase 5.8
more...
Compound
Neu4,5Ac2 12.1
Methylgalactoside 11.9
Isoscutellarein 11.9
Methylgalactoside 11.9
Apparicine 11.9
Neu5,9Ac2 11.6
Potassium sulfate 11.2
Potassium sulfate 11.2
Neu5,7Ac2 10.9
Voacangine 10.7
Coronaridine 10.2
KDN 10.1
Oseltamivir phosphate 10.1
Sialic acid 10.1
Neu5Ac 10.0
N-Glycolylneuraminic acid 9.9
AMAC 9.8
D-Fucose 9.6
disialyllactose 9.5
Neuraminic acid 9.5
Gal(beta1-3)GlcNAc 9.4
GM3 9.3
N-Acetyl-D-galactosamine 9.2
Amaranthin 9.2
ethyl 4-aminobenzoate 9.1
C6H12O6 9.0
N-acetylmannosamine 8.9
Ginkgetin 8.8
GA2 8.7
GM2 8.6
ibogamine 8.5
Zanamivir 8.3
GalNAc4S 8.3
2-anthracenecarboxylic acid 8.2
GalNAc 8.2
Triacetin 8.1
Bromophenol Blue 8.1
GD3 8.1
PNA 8.1
GM1 8.0
CDH 8.0
3-methoxyphenol 7.9
CMP 7.9
CMP 7.9
2-aminobenzamide 7.8
NEU 7.8
Chondroitin sulfate A 7.7
MAL 7.5
1-naphthyl acetate 7.5
Gb4 7.5
Sulfatide 7.5
Oseltamivir 7.5
Azure A 7.4
Rimantadine 7.4
beta-D-galactoside 7.4
2-aminobenzoic acid 7.3
2-aminobenzoic acid 7.3
phenyl carbamate 7.3
Lea 7.2
Lewis X 7.2
trifluoromethanesulfonic acid 7.1
DEN 7.1
Cer 7.1
UDP-N-acetylgalactosamine 7.1
Selectin 7.0
GlcNAc 7.0
trifluoromethanesulfonic acid 7.0
N-Acetylglucosamine 7.0
Diol 7.0
4-bromophenol 6.6
Stigmasterol 6.6
Benzocaine 6.6
GA1 6.6
acryloyl chloride 6.5
4-chloro-1-naphthol 6.4
1,2,4-benzenetriol 6.4
TCN 6.3
Nifurtimox 6.1
Galactose 6.1
keratan sulfate 6.0
more...