Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:3.1.1.53 (
sialidase
)
2,694
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Like in most eukaryotes, the linear chromosomes of
Trypanosoma cruzi
end in a nucleoprotein structure called the telomere, which is preceded by regions of variable length called subtelomeres. Together telomeres and subtelomeres are dynamic sites where DNA sequence rearrangements can occur without compromising essential interstitial genes or chromosomal synteny. Good examples of subtelomeres involvement are the expansion of human olfactory receptors genes, variant surface antigens in
Trypanosoma brucei
, and
Saccharomyces cerevisiae
mating types.
T. cruzi
telomeres are made of long stretches of the hexameric repeat 5'-TTAGGG-OH-3', and its subtelomeres are enriched in genes and pseudogenes from the large gene families RHS, TS and DGF1, DEAD/H-
RNA helicase
and N-acetyltransferase, intermingled with sequences of retrotransposons elements. In particular, members of the Trans-
sialidase
type II family appear to have played a role in shaping the current
T. cruzi
telomere structure. Although the structure and function of
T. cruzi
telomeric and subtelomeric regions have been documented, recent experiments are providing new insights into
T. cruzi
's telomere-subtelomere dynamics. In this review, I discuss the co-evolution of telomere, subtelomeres and the TS gene family, and the role that these regions may have played in shaping
T. cruzi
's genome.
...
PMID:An Evolutionary View of
Trypanosoma Cruzi
Telomeres. 3199 59
