Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:3.1.1.34 (lipoprotein lipase)
 7,025 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Fluorescein-labelled sulodexide pharmacokinetics and urinary excretion were studied in the rat after intravenous administration. The compound showed a pharmacokinetic pattern similar to that of heparin and the plasmatic levels were linearly correlated with anti-factor Xa activity and logarithmically with lipoprotein lipase activation. The compound is well eliminated by urinary route; the urinary recovery was 50% in 24 h and 67% 48 h after administration. The results obtained indicate that fluorescein labelling of glycosaminoglycans may be a valid tool for pharmacokinetics and distribution studies in the laboratory animals.
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PMID:Pharmacokinetics and distribution of a fluoresceinated glycosaminoglycan, sulodexide, in rats. Part I: Pharmacokinetics in rats. 407 5

Fluorescein-labelled glycosaminoglycans (F-GAG) were absorbed by the rat intestinal tract when administered in an anhydrous suspension consisting of vegetable fats and sodium taurocholate. A statistically significant regression between plasma levels of F-GAG and plasma lipoprotein lipase activities was found.
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PMID:Absorption by the rat intestinal tract of fluorescein-labelled pig duodenal glycosaminoglycans. 719 99