Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.8 (polynucleotide phosphorylase)
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Human Gene/Protein
PNPase 15.4
polynucleotide phosphorylase 15.3
SUPV3L1 14.4
SUV3 13.8
ribosomal protein S15 13.2
RNase E 13.1
RNA helicase) 12.6
REXO2 12.4
MTPAP 12.3
mitochondrial ribosomal protein S12 11.8
ribosomal protein S20 11.7
Endoribonuclease 11.4
GRSF1 11.3
Rrp4p 11.3
PRP22 11.3
HSP78 11.0
NUDT5 11.0
DEAD-box RNA helicase 10.9
Rrp43p 10.7
ThrRS 10.7
SP82 10.4
ribonuclease T2 10.4
ferritin-like protein 10.3
P12A 10.3
PRP2 10.3
LRPPRC 10.3
PreP 10.2
RNase III 10.2
PG8 10.1
DNase gamma 10.1
PRP16 10.1
RNA helicase 10.0
SLIRP 9.9
DEAD box RNA helicase 9.7
RNR1 9.7
UMP-CMP kinase 9.6
Poly(A) polymerase 9.5
tRNase Z 9.5
NIFL 9.4
PM-Scl 9.4
SLC5A1 9.4
CAT4 9.3
DEDD 9.3
phosphoglyceromutase 9.3
ISG20 9.1
ephrin-B3 9.1
RNR 9.1
enolase 9.0
ATP-dependent RNA helicase 9.0
stem-loop binding protein 9.0
DSS1 9.0
DNA-directed RNA polymerase 8.9
DNA-dependent DNA polymerase 8.9
CDP 8.8
IDP 8.8
PAP 8.8
parvulin 8.8
nucleic acid-binding protein 8.6
RNase 8.6
D-lactate dehydrogenase 8.6
Enolase 8.5
3'-5' exonuclease 8.5
HPC1 8.5
TCL1 8.4
thioredoxin 2 8.4
putative RNA helicase 8.4
BFP 8.4
Ro60 8.3
DEAD 8.3
3' exoribonuclease 8.3
RNA binding motif 8.2
CCA 8.2
PAP1 8.2
Ribonuclease 8.2
440 kDa 8.1
p200 8.1
nuclear respiratory factor-1 8.1
SIRT4 8.1
threonyl-tRNA synthetase 8.0
NAMPT 8.0
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Disease
RPC 7.8
Buchanan 7.7
non-gonococcal urethritis 6.7
myeloblastosis 6.5
pseudotuberculosis 6.1
paraproteinemia 6.1
Whipple's disease 6.0
Yersinia 5.6
CDA 5.5
progeria 5.3
Leigh syndrome 4.9
TTP 4.9
ACD 4.6
gestational trophoblastic disease 4.5
PCC 4.5
TTP 4.4
chlorosis 4.3
optic atrophy 4.3
cold 4.1
craniosynostosis 3.7
cutaneous melanoma 3.6
Dissociation 3.5
MRS 3.2
pheochromocytoma 3.2
Shiga 3.1
Barrett's esophagus 3.0
gastroenteritis 3.0
mimicry 2.9
Adhesion 2.9
metastatic melanoma 2.8
Shigella 2.8
idiopathic thrombocytopenic purpura 2.7
polio 2.7
melanoma 2.7
Mycoplasma 2.6
polycystic ovary syndrome 2.5
sarcoma 2.3
stomatitis 2.3
plague 2.2
dental caries 1.9
measles 1.8
Infection 1.8
Haemophilus 1.5
Mycobacterium 1.3
mole 1.3
encephalopathy 1.3
GSH 1.2
pancreatic cancer 1.1
psoriasis 1.1
mole 1.0
neuropathy 0.9
proteinuria 0.9
SDS 0.8
tuberculosis 0.8
neuroblastoma 0.7
infectious diseases 0.7
herpes simplex 0.6
cytomegalovirus 0.6
tumorigenesis 0.6
fits 0.5
hepatocellular carcinoma 0.3
multiple myeloma 0.3
lymphoma 0.3
tumor progression 0.1
virus infection -0.1
colorectal cancer -0.3
plaque -0.3
pneumonia -0.3
influenza -0.4
Parkinson's disease -0.5
adenocarcinoma -0.6
leukemia -1.1
cancer -1.2
Alzheimer's disease -1.3
tumor -1.6
carcinoma -1.8
breast cancer -1.9
Symptom
twitching 4.4
starvation 4.4
collapse 0.6
Drug
Cinnamon oil 10.4
CDP 8.2
EMB 7.4
-deoxyadenosine 6.0
APD 5.6
IFN-beta 5.5
Doxycycline 5.3
CTC 5.1
FeCl3 5.0
CTA 5.0
TTC 4.6
Glycerol 4.3
Alanine 4.0
Growth hormone 3.9
Growth hormone 3.9
Gel 3.2
NADH 3.0
Bifidobacterium 2.9
DNase I 2.4
ampicillin 1.4
lysine 1.2
Enzyme
polynucleotide phosphorylase 15.4
exoribonuclease 13.5
RNase PH 13.2
oligoribonuclease 12.5
purine nucleoside phosphorylase 12.3
poly(A) polymerase 11.8
EC 2.7.7.25 11.6
DHOdehase 11.0
RNase III 11.0
RNase D 10.9
ATP(CTP):tRNA nucleotidyltransferase 10.9
stringent factor 10.9
CMP kinase 10.1
dehydroquinase 9.6
3'-exonuclease 9.6
nucleoside phosphotransferase 9.6
tRNase Z 9.4
poly(A)-specific ribonuclease 9.1
enolase 9.0
RNase 8.9
adenine deaminase 8.8
RNA ligase 8.6
polyphosphate kinase 8.6
Escherichia coli exonuclease III 8.5
RNase T1 8.5
RNase 8.4
ribonuclease 8.2
ribonuclease 8.2
venom phosphodiesterase 8.2
DD-carboxypeptidase 8.0
RNase P 8.0
catechol 1,2-dioxygenase 7.9
phosphoglyceromutase 7.8
lactic acid dehydrogenase 7.6
lactic acid dehydrogenase 7.5
acetate kinase 7.5
DD-carboxypeptidase 7.5
uridine phosphorylase 7.2
tryptophanyl-tRNA synthetase 7.1
orotidine-5'-phosphate decarboxylase 7.0
disulfide reductase 7.0
tryptophanase 7.0
aspartokinase 6.8
aconitase 6.7
S1 nuclease 6.6
GAS 6.5
TRS 6.4
5'-nucleotidase 6.4
galactokinase 6.2
p-nitrophenylphosphatase 6.1
polynucleotide kinase 6.0
methionine adenosyltransferase 6.0
isocitrate dehydrogenase 6.0
phosphorylase 6.0
deoxycytidine kinase 6.0
PGM 6.0
micrococcal nuclease 6.0
6-phosphogluconate dehydrogenase 5.9
6-phosphogluconate dehydrogenase 5.9
transpeptidase 5.9
pullulanase 5.9
isoamylase 5.9
lactic acid dehydrogenase 5.8
phosphofructokinase 5.8
ClpP 5.8
endonuclease 5.8
tryptophan 2,3-dioxygenase 5.7
pyruvate kinase 5.7
LasR 5.6
IMP dehydrogenase 5.6
ribonucleotide reductase 5.5
adenylate kinase 5.5
cytidine deaminase 5.5
ribonucleotide reductase 5.5
myosin ATPase 5.3
ATP synthase 5.2
RNase H 5.0
RNA polymerase 4.9
apyrase 4.8
isocitrate dehydrogenase 4.8
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Compound
Isoguanosine 11.8
DEPA 11.5
DEPA 11.1
dADP 10.8
dCDP 10.4
dGDP 10.0
Poly C 10.0
Purine nucleoside 9.6
Thiostrepton 9.6
D 3 8.9
8-hydroxyguanosine 8.8
PAP 8.8
CDP 8.8
IDP 8.7
PAP 8.5
PAP 8.5
PAP 8.5
Chlortetracycline 8.2
3'-AMP 7.9
Actinomycin 7.7
methylguanosine 7.2
PH2 7.2
UDP 7.2
Guo 7.1
Hypoxanthine 6.9
dGTP 6.6
PNP 6.5
dGMP 6.3
decanoic acid 6.3
Daptomycin 6.1
decanoic acid 6.1
CMP 6.1
ACNU 6.1
CMP 6.0
Thioflavin T 6.0
1H-benzimidazole 6.0
GDP 5.9
CTP 5.9
adenylate 5.8
Actinomycin D 5.8
triethoxysilane 5.8
uridine 5.7
tetraphosphate 5.6
Adenine 5.6
CDA 5.5
ADP 5.5
ADP 5.5
TDP 5.5
PPi 5.4
ADP 5.4
T 1 5.4
GMP 5.4
dATP 5.4
Doxycycline 5.4
SPD 5.3
phosphite 5.3
UMP 5.3
fMet 5.2
40S 5.0
Adenine 4.9
dCTP 4.9
Mg2+ 4.8
Trypsin 4.8
Lac 4.7
Proline 4.6
PAM 4.5
PAM 4.5
ITP 4.4
HgCl2 4.3
TTC 4.3
sodium chloride 4.3
manganese 4.3
Cycloheximide 4.2
MgCl2 4.2
DEAE 4.1
phosphate 4.1
Alanine 4.0
ATP 4.0
TTP 4.0
perchloric acid 3.9
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