Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.8 (polynucleotide phosphorylase)
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Human Gene/Protein
PNPase 15.4
polynucleotide phosphorylase 15.3
SUPV3L1 14.4
SUV3 13.8
ribosomal protein S15 13.2
RNase E 13.1
RNA helicase) 12.6
REXO2 12.4
MTPAP 12.3
mitochondrial ribosomal protein S12 11.8
ribosomal protein S20 11.7
Endoribonuclease 11.4
GRSF1 11.3
Rrp4p 11.3
PRP22 11.3
HSP78 11.0
NUDT5 11.0
DEAD-box RNA helicase 10.9
Rrp43p 10.7
ThrRS 10.7
SP82 10.4
ribonuclease T2 10.4
P12A 10.3
ferritin-like protein 10.3
PRP2 10.3
LRPPRC 10.3
PreP 10.2
RNase III 10.2
PG8 10.1
DNase gamma 10.1
PRP16 10.1
RNA helicase 10.0
SLIRP 9.9
DEAD box RNA helicase 9.7
RNR1 9.7
UMP-CMP kinase 9.6
Poly(A) polymerase 9.5
tRNase Z 9.5
NIFL 9.4
SLC5A1 9.4
PM-Scl 9.4
CAT4 9.3
DEDD 9.3
phosphoglyceromutase 9.3
ISG20 9.1
ephrin-B3 9.1
RNR 9.1
enolase 9.0
ATP-dependent RNA helicase 9.0
stem-loop binding protein 9.0
DSS1 9.0
DNA-directed RNA polymerase 8.9
DNA-dependent DNA polymerase 8.9
CDP 8.8
IDP 8.8
PAP 8.8
parvulin 8.8
nucleic acid-binding protein 8.6
RNase 8.6
D-lactate dehydrogenase 8.6
Enolase 8.5
3'-5' exonuclease 8.5
HPC1 8.5
TCL1 8.4
putative RNA helicase 8.4
thioredoxin 2 8.4
BFP 8.4
Ro60 8.3
DEAD 8.3
3' exoribonuclease 8.3
RNA binding motif 8.2
CCA 8.2
PAP1 8.2
Ribonuclease 8.2
440 kDa 8.1
p200 8.1
nuclear respiratory factor-1 8.1
SIRT4 8.1
threonyl-tRNA synthetase 8.0
NAMPT 8.0
MGL 8.0
L24 7.9
RNase A 7.9
S-adenosylmethionine synthetase 7.9
caspase-activated DNase 7.9
purine nucleoside phosphorylase 7.8
OUT 7.8
RPC 7.8
RNA-associated 7.8
USP18 7.7
PH2 7.7
DEAD-box protein 7.7
Phosphorylase 7.7
glycolytic enzyme 7.7
PNP 7.6
nucleoside phosphorylase 7.6
MTH1 7.6
AMPS 7.5
L14 7.5
EMB 7.4
nuclear respiratory factor 1 7.4
cationic amino acid transporter 7.4
BMI-1 7.3
S14 7.3
helicase 7.2
tryptophanyl-tRNA synthetase 7.2
ribosomal protein 7.2
inorganic pyrophosphatase 7.1
mitochondrial transcription factor A 7.0
Poly 7.0
L-lactate dehydrogenase 6.9
uridine phosphorylase 6.9
Myc protein 6.9
L16 6.9
cyclin-dependent kinase inhibitor p27 6.9
endonuclease G 6.8
TFAM 6.8
p27(KIP1) 6.8
Fis1 6.8
aconitase 6.8
c-myc mRNA 6.7
elongation factor Tu 6.7
bcl-x 6.7
ribonuclease A 6.7
ND3 6.6
GAS 6.6
BMI1 6.6
SS1 6.5
tailless 6.5
I-1 6.5
phosphoglycerate mutase 6.5
EF-Tu 6.5
tRNA 6.4
MAPK1 6.4
non-catalytic 6.3
P27 6.3
CCAAT/enhancer-binding protein homologous protein 6.3
GTT 6.3
RNA-binding protein 6.2
MRP 6.2
DNA helicase 6.2
galactokinase 6.2
xylosidase 6.1
single-stranded DNA-binding protein 6.1
HIS3 6.0
Chymotrypsin 6.0
CMP 6.0
phosphofructokinase 6.0
forkhead transcription factor 6.0
ND6 6.0
elongation factor G 6.0
6-phosphogluconate dehydrogenase 6.0
StAR 6.0
MDA5 5.9
SF2 5.9
GDP 5.9
transcription elongation factor 5.9
CTP 5.9
5'-nucleotidase 5.9
deoxycytidine kinase 5.9
GMP 5.8
asp 5.8
endonuclease 5.8
prolyl isomerase 5.8
CAC 5.8
adenosine triphosphatase 5.7
RNA polymerase I 5.7
extracellular protein 5.7
interferon-beta 5.7
E.coli 5.7
RNA binding protein 5.7
pyruvate kinase 5.7
CBF1 5.7
Era 5.6
AED 5.6
UCP3 5.6
autoantigen 5.6
CDA 5.5
ribonucleotide reductase 5.5
cytidine deaminase 5.5
adenylate kinase 5.5
nucleotide pyrophosphatase 5.5
ADP 5.5
lipoamide dehydrogenase 5.5
cys 5.5
TdT 5.5
IFN-beta 5.4
CRS 5.4
ATP synthase 5.4
Rho 5.4
translocator protein 5.3
TRAP 5.3
ribonucleoprotein 5.3
signal recognition particle 5.2
apyrase 5.2
PH domain 5.2
RNase H 5.2
type I interferon 5.2
P450scc 5.2
translation initiation factor 5.1
TTP 5.1
HO-1 5.1
COX2 5.1
GroES 5.0
Leu5 5.0
Chlamydomonas 5.0
DNA-dependent protein kinase 4.9
isocitrate dehydrogenase 4.9
GAA 4.9
MOLT 4.8
eukaryotic translation initiation factor 4.8
AKT1 4.8
Trypsin 4.8
transcriptional activator 4.8
CIP1 4.7
ACG 4.7
c-MYC 4.7
PCC 4.7
SIRT1 4.7
K12 4.6
SSA 4.6
DNA polymerase alpha 4.6
Duffy 4.6
ADA 4.6
K10 4.5
DNA binding protein 4.5
AAG 4.5
NADH dehydrogenase 4.4
PKR 4.4
citrate synthase 4.4
glycogen phosphorylase 4.4
chaperonin 4.3
Myosin 4.3
binding peptide 4.2
hypoxanthine-guanine phosphoribosyltransferase 4.2
thioredoxin reductase 4.2
RNP 4.2
ATP 4.0
WAF1 4.0
IkappaBalpha 4.0
transcriptional repressor 4.0
Walker 3.9
IMP 3.9
porin 3.8
AMPK 3.8
chimeric protein 3.8
AMP 3.7
Growth hormone 3.7
thioredoxin 3.7
housekeeping 3.6
acetyltransferase 3.6
aminopeptidase 3.6
pseudogene 3.6
transcriptional regulator 3.5
Spin 3.5
ALP 3.4
SWI 3.4
DNA-binding protein 3.4
glutamate dehydrogenase 3.3
DNase 3.3
GTP 3.3
p50 3.3
TCA 3.2
MRS 3.2
ATP-binding cassette 3.2
glutamine synthetase 3.1
adenosine deaminase 3.1
alpha-amylase 3.1
UTR 3.1
interferon 3.1
c-myc 3.1
hexokinase 3.1
MYC 3.1
proline-rich 3.1
dystrophin 3.0
ATPase 3.0
integrase 3.0
NADH 3.0
cyclin-dependent kinase 3.0
novel gene 3.0
X-linked 3.0
fur 3.0
Met 2.9
Mol 2.9
phosphodiesterase 2.9
S100 2.9
RANTES 2.9
acid phosphatase 2.8
AST 2.8
tissue plasminogen activator 2.8
ORF 2.8
C-C 2.8
Net 2.8
cytochrome c oxidase 2.7
long chain 2.7
peroxisome proliferator-activated receptor gamma 2.7
glucose transporter 2.6
cytochrome 2.6
NADP 2.6
membrane-bound 2.6
AMP-activated protein kinase 2.6
p27 2.5
thymus 2.5
rhabdomyosarcoma 2.5
oxidoreductase 2.5
polypeptide 2.5
proto-oncogene 2.4
DNase I 2.4
Pseudomonas 2.4
xanthine oxidase 2.4
IFN 2.3
unknown function 2.3
CAT 2.3
peptidase 2.3
Polymerase 2.3
heat shock protein 2.2
alkaline phosphatase 2.2
chymotrypsin 2.2
membrane protein 2.1
THP 2.1
more...
Disease
RPC 7.8
Buchanan 7.7
non-gonococcal urethritis 6.7
myeloblastosis 6.5
pseudotuberculosis 6.1
paraproteinemia 6.1
Whipple's disease 6.0
Yersinia 5.6
CDA 5.5
progeria 5.3
Leigh syndrome 4.9
TTP 4.9
ACD 4.6
gestational trophoblastic disease 4.5
PCC 4.5
TTP 4.4
chlorosis 4.3
optic atrophy 4.3
cold 4.1
craniosynostosis 3.7
cutaneous melanoma 3.6
Dissociation 3.5
MRS 3.2
pheochromocytoma 3.2
Shiga 3.1
Barrett's esophagus 3.0
gastroenteritis 3.0
mimicry 2.9
Adhesion 2.9
metastatic melanoma 2.8
Shigella 2.8
idiopathic thrombocytopenic purpura 2.7
polio 2.7
melanoma 2.7
Mycoplasma 2.6
polycystic ovary syndrome 2.5
sarcoma 2.3
stomatitis 2.3
plague 2.2
dental caries 1.9
measles 1.8
Infection 1.8
Haemophilus 1.5
Mycobacterium 1.3
mole 1.3
encephalopathy 1.3
GSH 1.2
pancreatic cancer 1.1
psoriasis 1.1
mole 1.0
neuropathy 0.9
proteinuria 0.9
SDS 0.8
tuberculosis 0.8
neuroblastoma 0.7
infectious diseases 0.7
herpes simplex 0.6
cytomegalovirus 0.6
tumorigenesis 0.6
fits 0.5
hepatocellular carcinoma 0.3
multiple myeloma 0.3
lymphoma 0.3
tumor progression 0.1
virus infection -0.1
colorectal cancer -0.3
plaque -0.3
pneumonia -0.3
influenza -0.4
Parkinson's disease -0.5
adenocarcinoma -0.6
leukemia -1.1
cancer -1.2
Alzheimer's disease -1.3
tumor -1.6
carcinoma -1.8
breast cancer -1.9
Symptom
twitching 4.4
starvation 4.4
collapse 0.6
Drug
Cinnamon oil 10.4
CDP 8.2
EMB 7.4
-deoxyadenosine 6.0
APD 5.6
IFN-beta 5.5
Doxycycline 5.3
CTC 5.1
FeCl3 5.0
CTA 5.0
TTC 4.6
Glycerol 4.3
Alanine 4.0
Growth hormone 3.9
Growth hormone 3.9
Gel 3.2
NADH 3.0
Bifidobacterium 2.9
DNase I 2.4
ampicillin 1.4
lysine 1.2
Enzyme
polynucleotide phosphorylase 15.4
exoribonuclease 13.5
RNase PH 13.2
oligoribonuclease 12.5
purine nucleoside phosphorylase 12.3
poly(A) polymerase 11.8
EC 2.7.7.25 11.6
DHOdehase 11.0
RNase III 11.0
RNase D 10.9
ATP(CTP):tRNA nucleotidyltransferase 10.9
stringent factor 10.9
CMP kinase 10.1
dehydroquinase 9.6
3'-exonuclease 9.6
nucleoside phosphotransferase 9.6
tRNase Z 9.4
poly(A)-specific ribonuclease 9.1
enolase 9.0
RNase 8.9
adenine deaminase 8.8
RNA ligase 8.6
polyphosphate kinase 8.6
Escherichia coli exonuclease III 8.5
RNase T1 8.5
RNase 8.4
ribonuclease 8.2
ribonuclease 8.2
venom phosphodiesterase 8.2
DD-carboxypeptidase 8.0
RNase P 8.0
catechol 1,2-dioxygenase 7.9
phosphoglyceromutase 7.8
lactic acid dehydrogenase 7.6
lactic acid dehydrogenase 7.5
acetate kinase 7.5
DD-carboxypeptidase 7.5
uridine phosphorylase 7.2
tryptophanyl-tRNA synthetase 7.1
orotidine-5'-phosphate decarboxylase 7.0
disulfide reductase 7.0
tryptophanase 7.0
aspartokinase 6.8
aconitase 6.7
S1 nuclease 6.6
GAS 6.5
TRS 6.4
5'-nucleotidase 6.4
galactokinase 6.2
p-nitrophenylphosphatase 6.1
polynucleotide kinase 6.0
methionine adenosyltransferase 6.0
isocitrate dehydrogenase 6.0
phosphorylase 6.0
deoxycytidine kinase 6.0
PGM 6.0
micrococcal nuclease 6.0
6-phosphogluconate dehydrogenase 5.9
6-phosphogluconate dehydrogenase 5.9
transpeptidase 5.9
pullulanase 5.9
isoamylase 5.9
lactic acid dehydrogenase 5.8
phosphofructokinase 5.8
ClpP 5.8
endonuclease 5.8
tryptophan 2,3-dioxygenase 5.7
pyruvate kinase 5.7
LasR 5.6
IMP dehydrogenase 5.6
ribonucleotide reductase 5.5
adenylate kinase 5.5
cytidine deaminase 5.5
ribonucleotide reductase 5.5
myosin ATPase 5.3
ATP synthase 5.2
RNase H 5.0
RNA polymerase 4.9
apyrase 4.8
isocitrate dehydrogenase 4.8
succinic dehydrogenase 4.7
TdT 4.5
diaphorase 4.5
NADH dehydrogenase 4.4
chaperonin 4.3
citrate synthase 4.3
thioredoxin reductase 4.2
hypoxanthine-guanine phosphoribosyltransferase 4.1
DNase 4.1
peroxiredoxin 4.1
MDP 4.0
succinate dehydrogenase 4.0
chymotrypsin 4.0
DNA ligase 4.0
diaphorase 4.0
beta-galactosidase 3.9
complex I 3.9
phosphodiesterase 3.8
AMPK 3.8
transcriptase 3.8
DNA polymerase 3.7
proteinase K 3.4
xylanase 3.4
AMP-activated protein kinase 3.3
glutamate dehydrogenase 3.3
glutamate dehydrogenase 3.3
cytochrome oxidase 3.3
xylanase 3.3
glutamate dehydrogenase 3.3
ATPase 3.2
glutamine synthetase 3.1
chloramphenicol acetyltransferase 3.1
adenosine deaminase 3.1
adenosine deaminase 3.1
alpha-amylase 3.1
hexokinase 3.1
AST 2.9
AMPK 2.8
acid phosphatase 2.8
aldehyde dehydrogenase 2.8
urease 2.6
lactate dehydrogenase 2.6
urease 2.6
reverse transcriptase 2.5
xanthine oxidase 2.4
trypsin 2.4
alkaline phosphatase 2.2
tissue plasminogen activator 2.0
superoxide dismutase 1.2
aspartate aminotransferase 1.0
alanine aminotransferase 0.7
catalase 0.7
proteasome 0.6
thrombin 0.4
caspase-3 0.3
luciferase 0.2
protein kinase 0.1
peroxidase -0.6
Compound
Isoguanosine 11.8
DEPA 11.5
DEPA 11.1
dADP 10.8
dCDP 10.4
dGDP 10.0
Poly C 10.0
Purine nucleoside 9.6
Thiostrepton 9.6
D 3 8.9
8-hydroxyguanosine 8.8
PAP 8.8
CDP 8.8
IDP 8.7
PAP 8.5
PAP 8.5
PAP 8.5
Chlortetracycline 8.2
3'-AMP 7.9
Actinomycin 7.7
methylguanosine 7.2
PH2 7.2
UDP 7.2
Guo 7.1
Hypoxanthine 6.9
dGTP 6.6
PNP 6.5
dGMP 6.3
decanoic acid 6.3
Daptomycin 6.1
decanoic acid 6.1
CMP 6.1
ACNU 6.1
CMP 6.0
Thioflavin T 6.0
1H-benzimidazole 6.0
GDP 5.9
CTP 5.9
adenylate 5.8
Actinomycin D 5.8
triethoxysilane 5.8
uridine 5.7
tetraphosphate 5.6
Adenine 5.6
CDA 5.5
ADP 5.5
ADP 5.5
TDP 5.5
PPi 5.4
ADP 5.4
T 1 5.4
GMP 5.4
dATP 5.4
Doxycycline 5.4
SPD 5.3
phosphite 5.3
UMP 5.3
fMet 5.2
40S 5.0
Adenine 4.9
dCTP 4.9
Mg2+ 4.8
Trypsin 4.8
Lac 4.7
Proline 4.6
PAM 4.5
PAM 4.5
ITP 4.4
HgCl2 4.3
TTC 4.3
sodium chloride 4.3
manganese 4.3
Cycloheximide 4.2
MgCl2 4.2
DEAE 4.1
phosphate 4.1
Alanine 4.0
ATP 4.0
TTP 4.0
perchloric acid 3.9
AMP 3.9
toluene 3.8
Guo 3.8
IMP 3.8
acridine 3.6
propylene glycol 3.6
propylene glycol 3.5
THE 3.5
nicotinamide 3.4
2-mercaptoethanol 3.4
ALP 3.4
PEI 3.4
PEI 3.4
Resveratrol 3.3
UTP 3.2
betaine 3.2
GTP 3.2
pyrimidine 3.1
Triton X-100 3.1
pyrimidine 3.1
NADH 3.0
acrylamide 3.0
hexose 2.9
hexose 2.9
hexose 2.9
A 1 2.8
HCl 2.7
Adenosine 2.7
6-12 2.6
Sucrose 2.6
Phe 2.6
2-oxoglutarate 2.6
salt 2.5
H2S 2.4
cyanide 2.4
Salt 2.4
hexose 2.3
TCA 2.3
CAT 2.3
CAT 2.3
BCG 2.3
phosphorus 2.2
Sodium 2.2
CAT 2.2
AMPA 2.2
THP 2.1
phosphoric acid 2.1
THP 2.1
NADP 2.0
tryptophan 1.9
tryptophan 1.9
tryptophan 1.9
NADPH 1.8
NADPH 1.8
DNA 1.8
ammonium 1.8
PEG 1.8
His 1.8
phenol 1.7
glycerol 1.7
mercury 1.7
tryptophan 1.7
bromide 1.6
methionine 1.6
formaldehyde 1.5
proline 1.5
chlorine 1.4
Optimal 1.3
fluorine 1.3
vinyl 1.3
chloroform 1.2
PEG 1.2
cysteine 1.2
arginine 1.2
formaldehyde 1.2
GSH 1.1
GSH 1.1
MIC 1.1
zinc 1.0
sodium 0.9
alanine 0.9
MDA 0.9
SDS 0.7
lysine 0.7
pyridine 0.7
cobalt 0.7
cAMP 0.6
methanol 0.6
H2O2 0.5
oxygen 0.5
urea 0.5
tyrosine 0.4
serine 0.4
Gly 0.4
Asp 0.3
cadmium 0.3
acetic acid 0.3
hydrogen 0.1
threonine 0.0
Dec -0.0
NH2 -0.1
glucose -0.2
sulfate -0.3
leucine -0.5
TNF -0.5
galactose -0.8
calcium -0.9
CO2 -1.0
copper -1.1
potassium -1.1
nitric oxide -1.2
water -1.7
nitrogen -1.8
Clin -3.1