Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.8 (
polynucleotide phosphorylase
)
723
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hypophysectomy in rats is accompanied by a significant rise in
PNPase
activity in ribosomal fractions of the liver. Injection of
growth hormone
into operated animals produces inhibition of
PNPase
activity. The linear dependence "dose-response" was recorded with the use of a dosage range of 5 to 100 micrograms/animal. The action of
growth hormone
was most pronounced 18 hours following its single injection.
...
PMID:[Importance of the growth hormone in regulating polynucleotide phosphorylase activity in the rat liver]. 737 Apr 13
Growth hormone (1 microgram/ml) inoculated into the primary culture of rat hepatocytes and incubated for 3 hours at 37 degrees C decreases 2-fold the activity of
polynucleotide phosphorylase
(
PNPase
). In the culture of hepatocytes from hypophysectomized rats, the basal activity of
PNPase
is significantly higher as compared with that in the culture of hepatocytes from intact animals. The most pronounced inhibitory effect of
growth hormone
on
PNPase
was seen in the culture of hepatocytes from hypophysectomized animals.
...
PMID:[Effect of growth hormone on polynucleotide phosphorylase activity in a primary monolayer culture of rat hepatocytes]. 747 Jun 4
