Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.8 (
polynucleotide phosphorylase
)
723
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Remarkable activity of various enzymes involved in adenine nucleotide degradation has been revealed in the endothelium recently. Using the highly sensitive radiochromatographic methods, the activities of 5'-nucleotidase, EC: 3.1.3.5. (5'-Nase),
adenine deaminase
, EC: 3.5.4.4. (ADase), and purine nucleoside phosphorylase, EC: 2.4.2.5. (PN-Pase) were estimated in the endothelium from normal human aortas characterized by a regular arrangement of cells and in the endothelium from atherosclerotic aortas characterized by different size and often multinucleated cells. Activities of 5'-Nase and ADase in the endothelial cells of atherosclerotic aortas were significantly higher than activities in normal ones. However, the activity of
PNPase
was approximately on the same level in both aortas. The above findings indicate a shift in the activity of 5'-Nase and ADase, which might be a result of the atherosclerotic process as well as the aggregation of platelets.
...
PMID:Activity of some adenine nucleotide degradation enzymes in human atherosclerotic aorta endothelium. 818 97
