Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.8 (polynucleotide phosphorylase)
723 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Dodecanucleotide CpCpUpGpCpUpUpUpUpGpCpU corresponding to 3'-terminus of influenza virus RNA has been synthesized. The initial blocks CpCpU, GpCpU, pGpCpU and pGpCpUp were prepared enzymatically in the presence of ribonucleases of different substrate specificity and polynucleotide phosphorylase M. luteus. pUpUpU was obtained by enzymatic degradation of polyuridilic acid. The initial blocks were joined by T4 RNA-ligase.
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PMID:[Enzymatic synthesis of oligonucleotides corresponding to the 3'-terminus of influenza virus RNA]. 667 59