Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.7 (DNA polymerase)
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Human Gene/Protein
DNA-directed DNA polymerase 10.9
DNA polymerase 10.9
DNA polymerase alpha 10.9
Thioredoxin reductase (NADPH) 10.9
PIGS protein 10.9
DNA-dependent DNA polymerase 10.9
DNA polymerase beta 10.9
RAD30B 10.6
DNA polymerase gamma 10.4
deoxynucleotidyltransferase 10.3
DNA polymerase N 10.3
POLA2 10.1
POLE1 10.1
3'-5' exonuclease 10.0
beta-polymerase 10.0
DNA primase 10.0
Nei-like 2 9.9
155kD 9.9
POLD4 protein 9.9
56 AA 9.9
NG26 9.9
RNA nucleotidyltransferase (DNA-directed) 9.9
adenylate kinase 3-like 1 9.9
polg 9.9
Pol lambda 9.8
DNA polymerase-alpha 9.7
DNA polymerase lambda 9.5
POLN 9.5
POLQ 9.5
RNA-directed DNA polymerase 9.5
Mitochondrial DNA polymerase gamma 9.5
XPV 9.4
putative DNA polymerase 9.4
DNA polymerase delta 9.3
POLE4 9.3
PolB 9.3
POLG protein 9.3
PDIP1 9.3
TRAF interacting protein 9.3
X-ray repair cross-complementing protein 3 9.3
pol protein 9.2
DNA polymerase theta 9.2
DNA ligase III 9.2
POLD2 9.2
DNA polymerase kappa 9.2
Pol mu 9.2
DPB2 9.2
POLA1 9.1
polynucleotide ligase 9.1
POLH 9.1
p12 subunit 9.1
C1orf124 9.1
deoxycytidyl transferase 9.1
POLD4 9.0
POLK 9.0
RP-A 9.0
RFC140 9.0
Pol iota 8.9
POLD3 8.9
DNA polymerase iota 8.9
POLB 8.9
p180 8.9
tetratricopeptide repeat domain 3 8.9
bcl-2-JH 8.9
MGC5306 8.9
TGF-beta activated kinase 8.9
MBD4 protein 8.9
EXOG 8.9
putative exonuclease 8.9
replication factor C 8.9
DNA polymerase zeta 8.8
DNA ligase I 8.8
DNA ligase 1 8.8
xeroderma pigmentosum variant 8.7
REV3 8.7
flap endonuclease 1 8.7
POLG 8.7
YCL1 8.7
single-stranded DNA-binding protein 8.7
RNA polymerase II largest subunit 8.7
more...
Disease
XPV 9.5
Chronic herpes simplex 9.3
herpes 2 9.3
myeloblastosis 8.6
Adenoviral conjunctivitis 8.5
Alpers 8.3
TSC3 8.3
Australia antigen positive 8.3
Rabbitpox 7.9
Vaccinia virus infection 7.8
dVIN 7.7
Steroid-sensitive nephrotic syndrome 7.3
ACCCA 7.3
endometrial clear cell carcinoma 7.2
Egg drop syndrome 7.2
Increased drug resistance 7.1
Bovine papular stomatitis 7.0
TTP 6.9
oral neoplasm 6.9
Transient proteinuria 6.8
activation of latent virus 6.8
ACV 6.6
Goatpox 6.6
TTP 6.4
Xeroderma 6.3
Chronic progressive external ophthalmoplegia 6.3
Primary HIV infection 6.3
Ehrlich Ascites Tumor 6.3
Sheeppox 6.2
XP-A 6.0
Lymphocystis disease 6.0
Herpesvirus infection 6.0
XPE 5.9
Anaplastic Lymphoma 5.8
polioencephalitis 5.8
pseudocowpox 5.8
Camelpox 5.7
white leg 5.7
FANCJ 5.7
xeroderma pigmentosum 5.7
XPG 5.6
mammillitis 5.5
avian sarcoma 5.5
reticuloendotheliosis 5.5
canities 5.5
herpes simplex 5.5
XPB 5.5
HNA 5.5
necrospermia 5.5
Takahara 5.4
myxosarcoma 5.4
FXTAS 5.3
B virus infection 5.3
Rowell's syndrome 5.3
Recurrent seizures 5.3
FIP 5.3
mouse leukemia L1210 5.2
African swine fever 5.2
Argininosuccinic aciduria 5.2
Pearson's syndrome 5.2
lymphoblastoma 5.1
HSV infection 5.1
GAN 5.1
Mitochondrial DNA depletion 5.1
angioimmunoblastic lymphadenopathy with dysproteinemia 5.1
XPF 5.1
Rous sarcoma 5.1
avian leukosis 5.0
herpes 5.0
AKV 5.0
AILD 5.0
CMCT 5.0
CMV retinitis 5.0
trimethylaminuria 5.0
Complex I deficiency 4.9
Gyrate atrophy 4.9
Epithelioma 4.8
hypothalamic disorder 4.8
chronic active hepatitis 4.8
cytomegalovirus 4.8
more...
Symptom
Sensory ataxia 6.8
Ataxic 6.3
penile lesion 6.3
abiotrophy 4.5
No toxic effect 4.5
ophthalmoplegia 4.5
Halo 3.6
dark urine 2.7
Fluctuation 2.6
autodigestion 2.6
nasal discharge 2.5
ataxia 2.2
dysarthria 2.2
Spots 2.0
blepharospasm 1.9
adenitis 1.7
neuralgia 1.7
starvation 1.7
night sweats 1.6
CSR 1.4
chills 1.1
livedo 1.1
neurological disability 1.0
DNA marker 1.0
emaciation 0.8
eds 0.8
collapse 0.7
pallor 0.6
anorexia 0.4
lethargy 0.4
HSA 0.3
photophobia 0.2
abdominal discomfort 0.1
incoordination 0.1
cerebellar ataxia 0.1
hepatomegaly -0.0
leg pain -0.1
twitching -0.1
apathy -0.1
chorea -0.2
skin irritation -0.2
rhinorrhea -0.3
diarrhea -0.3
nausea -0.3
tachypnea -0.4
exhaustion -0.5
sore throat -0.6
hypotonia -0.6
myalgia -0.8
weakness -0.9
Ill -1.0
neck pain -1.1
fatigue -1.1
vomiting -1.1
agitation -1.1
hepatosplenomegaly -1.2
wheezing -1.4
nausea and vomiting -1.4
splenomegaly -1.4
hyperoxia -1.5
hypothermia -1.6
cough -1.7
hemoptysis -1.7
tremor -1.7
spasticity -1.8
respiratory distress -1.8
spasm -2.0
abdominal pain -2.1
headache -2.1
seizures -2.1
angina -2.5
insomnia -2.5
thinning -2.6
erythema -2.8
dyspnea -2.9
acidity -3.0
pain -4.3
Drug
2'-Deoxythymidine 10.9
1,N6-Ethenoadenine 8.9
Denavir 8.5
Lobucavir 8.1
Lobenzarit disodium 7.9
Reverset 7.9
2'-Deoxyadenosine 7.8
Alovudine 7.7
Ara-A 7.5
Cidofovir 7.4
Fialuridine 7.3
HPMPC 7.3
Hepatitis B immune globulin 7.2
CXN 7.2
Fomivirsen 7.1
CCl2F2 7.0
Maribavir 7.0
Valcyte 6.9
Zovirax 6.6
Histidinol 6.6
Clofarabine 6.6
Equilin 6.5
Anthramycin 6.5
Acyclovir 6.5
Troxacitabine 6.5
PFA 6.4
Foscavir 6.4
Telbivudine 6.1
Tora 6.1
Neocarzinostatin 6.1
Adozelesin 6.1
Entecavir 6.1
Entecavir 6.1
PMEA 6.0
Ganciclovir 6.0
Deoxyadenosine 5.9
Irofulven 5.9
AC2 5.9
Interferon beta-1a 5.8
-deoxyadenosine 5.7
Adefovir dipivoxil 5.5
Exelon 5.5
Valganciclovir 5.4
Mizoribine 5.3
ddI 5.3
Solon 5.2
ROX 5.2
Diamminedichloroplatinum 5.2
Epidoxorubicin 5.1
Sinefungin 5.1
Magnesium chloride 5.0
AZT 4.8
AZT 4.7
FCV 4.6
Gold sodium thiomalate 4.5
Etravirine 4.4
DNase I 4.4
Pirarubicin 4.3
Zinc sulfate 4.3
Zinc sulfate 4.3
Ddc 4.3
EFV 4.2
CTT 4.2
Aricept 4.1
Aztec 4.1
Syrup 4.1
CMX 4.1
PMPA 4.1
BLM 3.8
KCL 3.8
Pyridoxal phosphate 3.7
Fragment 3.7
Vitamin K2 3.7
Myricetin 3.6
AGG 3.6
Podophyllum 3.5
Opium 3.5
Peridex 3.5
Mycophenolic acid 3.4
CrCl3 3.3
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Enzyme
DNA polymerase 10.9
DNase V 10.6
exodeoxyribonuclease 9.6
endoribonuclease V 8.9
Escherichia coli exonuclease III 8.6
3'-exonuclease 8.6
deoxynucleoside monophosphate kinase 8.5
dTTPase 8.4
dCMP hydroxymethylase 8.4
DNA 3'-phosphatase 8.4
UmuD protein 8.2
DNA ligase 8.2
DNA ligase 8.2
exonuclease V 8.1
endodeoxyribonuclease 8.1
thymidylate kinase 8.0
RNase H 7.9
exonuclease VII 7.9
RNase D 7.8
lambda exonuclease 7.8
AP lyase 7.8
kanamycin kinase 7.7
EC 2.7.7.3 7.7
exonuclease I 7.6
dCTPase 7.5
polynucleotide kinase 7.5
dCMP deaminase 7.4
hypoxanthine-DNA glycosylase 7.4
histidinol phosphate phosphatase 7.4
dichloromethane dehalogenase 7.4
dGTPase 7.3
deoxycytidine deaminase 7.3
3'-phosphatase 7.2
endonuclease V 7.0
opine dehydrogenase 6.9
LexA repressor 6.8
trans-N-deoxyribosylase 6.5
streptomycin adenylyltransferase 6.5
dCTP deaminase 6.5
ribonucleotide reductase 6.5
dUTPase 6.5
ribonucleotide reductase 6.5
thymidine kinase 6.4
deoxyribonuclease 6.4
aminodeoxychorismate synthase 6.3
venom phosphodiesterase 6.3
nucleoside diphosphokinase 6.3
Dm-dNK 6.3
deoxyguanosine kinase 6.3
holo-ACP synthase 6.3
deoxycytidine kinase 6.3
S-formylglutathione hydrolase 6.0
reverse transcriptase 6.0
deoxyribonuclease 6.0
endonuclease 5.9
DNase 5.9
Fpg protein 5.8
endonuclease VII 5.7
IMP dehydrogenase 5.7
dCTP deaminase 5.7
AlkA 5.6
factor C 5.6
ATase 5.5
thymidylate synthase 5.5
poly(A) polymerase 5.5
uridine kinase 5.5
CMP-KDO synthetase 5.4
1-deoxy-D-xylulose-5-phosphate reductoisomerase 5.4
D-amino acid aminotransferase 5.4
TdT 5.4
guanylate kinase 5.4
PAPS reductase 5.3
topoisomerase 5.2
GDP-mannose 4,6-dehydratase 5.2
S1 nuclease 5.2
PabB 5.2
TUT 5.2
topoisomerase 5.2
GTP cyclohydrolase II 5.1
enzyme X 5.0
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Compound
benzyl chloroacetate 10.9
2,4-Difluorotoluene 10.9
Eupaformosanin 10.9
C8H7Br3O3 10.9
Cytosine arabinoside monophosphate 10.9
1,2-dibromo-2-methylpropane 10.9
4,4'-Diacetyldiphenylurea 10.9
Bisbrusatolyl malonate 10.9
DDUG 9.9
Psychotrine 9.9
DDUG 9.9
5-HP 9.9
C18H14O8 9.9
Aphidicolin 9.7
Aphidicolin 9.7
Variotin 9.3
Cyclo-C 9.3
ethylenesulfonic acid 9.3
Digallic acid 9.3
3'-Deoxy-3'-fluorothymidine 9.3
Microlenin 9.3
Psychotrine 9.3
4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 9.3
4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 9.3
C2B4 9.3
ethylenesulfonic acid 9.3
DNAP 9.2
phosphonoacetic acid 9.1
dCTP 9.1
deoxyribose-5-phosphate 9.1
dGTP 9.0
dCMP 8.9
C5H5N5O 8.9
4'-Epiadriamycin 8.9
Synthalin 8.9
U-20,661 8.9
N-Trifluoroacetyladriamycin 8.9
APTP 8.9
arsonoacetic acid 8.9
4,6-Diamino-5-formamidopyrimidine 8.9
Calcium elenolate 8.9
dITP 8.7
Deoxyribonolactone 8.7
dATP 8.7
dGMP 8.6
5-Formyluracil 8.5
Eugeniin 8.5
6-Methoxypurine 8.5
acid blue 40 8.5
C20H24O6 8.5
Stubomycin 8.5
TTP 8.5
ARA-AMP 8.3
1,N6-Ethenodeoxyadenosine 8.3
Foscarnet sodium 8.3
1-chloro-2-isocyanatoethane 8.3
Ara-T 8.2
Penciclovir 8.2
1,5-anhydrohexitol 8.1
Granaticin 8.1
benzyl bromoacetate 8.1
6-Mercaptopurine riboside 8.1
Purine riboside 8.1
DAMP 8.1
Lucidin 8.0
Foscarnet 7.9
Anticapsin 7.9
Purpuromycin 7.9
ara-AMP 7.7
ara-AMP 7.7
PPA 7.7
hexanediamide 7.5
Ara-G 7.5
1,5-anhydrohexitol 7.5
Fagaronine 7.5
Ara-G 7.5
Cidofovir 7.5
Adenine arabinoside 7.5
dCDP 7.4
trans-Diamminedichloroplatinum(II) 7.4
more...