Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.7 (DNA polymerase)
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Human Gene/Protein
DNA polymerase 11982
DNA polymerase alpha 1828
Mol 1503
Sep 1145
DNA polymerase beta 1127
pol 1124
Pol 915
ATP 607
endonuclease 589
proliferating cell nuclear antigen 530
thymus 475
helicase 466
polypeptide 427
DNA ligase 349
thymidine kinase 341
RNase H 297
Gen 296
DNA polymerase gamma 291
3'-5' exonuclease 277
DNA polymerase delta 248
DNA primase 227
Polymerase 196
p53 191
DNA-dependent DNA polymerase 188
ATPase 179
mer 169
NMR 155
deoxyribonuclease 155
single-stranded DNA-binding protein 142
DNA helicase 139
ribonucleotide reductase 135
surface antigen 132
TdT 125
interferon 124
single-stranded DNA binding protein 121
telomeric 118
nucleotide pyrophosphatase 115
DNA-binding protein 114
RNase 101
DNase 101
DNA binding protein 100
tRNA 99
ADP 97
fused 96
DNA polymerase-alpha 96
histone 95
TTP 95
alpha, beta 94
glycoprotein 94
ara 93
DNase I 92
replication factor C 89
SDS 88
CTP 87
POLG 79
topoisomerase I 78
thioredoxin 77
DNA ligase I 76
GTP 74
XRCC1 74
RNA-directed DNA polymerase 71
A-T 70
lymphoid 69
dihydrofolate reductase 67
alkaline phosphatase 66
E.coli 66
DNA gyrase 66
dimeric 65
phosphorylating 65
phosphatase 65
flap endonuclease 1 63
RPA 61
AMP 60
cyclin 59
Pseudomonas 58
Poly 57
RNA polymerase II 56
gene 4 54
p21 54
thymidylate synthase 53
serum albumin 52
SSB 52
uracil-DNA glycosylase 52
poly(ADP-ribose) polymerase 52
ACS 50
kit 50
PARP 50
DNA ligase III 49
RFC) 49
RNA polymerase I 47
ubiquitin 47
p66 47
Chk1 47
integrase 46
DNA polymerase eta 45
deoxynucleotidyltransferase 44
Proliferating cell nuclear antigen 43
NTP 40
p180 40
APE1 39
Cdc45 39
DNA repair enzyme 39
DNA topoisomerase 39
xeroderma pigmentosum variant 39
ATR 38
beta-polymerase 38
reductase 37
REV3 36
p68 35
insulin 34
ORF 34
unknown function 34
DNA-directed DNA polymerase 33
REV1 33
thymidylate synthetase 33
XPV 33
PolB 33
MSH2 33
c-myc 32
Met 32
cyclin A 32
deoxyribonuclease I 32
IFN 32
beta-globin 31
DNA polymerase lambda 31
p51 31
deoxycytidine kinase 31
p58 30
K12 30
endonuclease III 30
p12 30
ATM 30
core protein 29
DNA topoisomerase I 29
polynucleotide ligase 29
nuclear protein 29
RFC 29
DNA-binding domain 29
peroxidase 29
cryptic 29
FEN1 29
BRCA1 28
cytokine 28
thymidylate kinase 28
Sp1 28
Ki-67 28
NAD 28
POLQ 27
glutathione S-transferase 27
threonine 27
ribonucleoprotein 27
ras 26
CD4 26
caspase-3 26
DNA polymerase zeta 26
SOD 26
hinge 26
OGG1 26
lipopolysaccharide 26
interacting protein 25
more...
Disease
cancer 1037
herpes simplex 684
tumor 617
HIV 522
hepatitis B 514
cytomegalovirus 417
immunodeficiency 384
leukemia 334
Epstein 215
carcinogenesis 212
myeloblastosis 208
chronic hepatitis 164
AIDS 163
hepatitis 161
herpes 148
hepatocellular carcinoma 139
carcinoma 136
virus infection 126
plaque 115
vaccinia 115
varicella 110
breast cancer 97
TTP 95
TTP 95
infectious diseases 94
sarcoma 90
SDS 88
lymphoma 83
tumorigenesis 79
cold 79
xeroderma pigmentosum 79
Mycobacterium 74
Infection 68
colorectal cancer 62
chronic active hepatitis 57
Rous sarcoma 55
acute myeloid leukemia 50
tuberculosis 49
melanoma 48
cirrhosis 47
ATM 46
anemia 43
Kaposi's sarcoma 42
Adenovirus 42
viremia 37
multiple myeloma 37
encephalitis 36
lung cancer 36
African swine fever 36
squamous cell carcinoma 36
skin cancer 35
tumor growth 35
hepatitis C 34
mammary tumor 34
influenza 33
neuropathy 33
acute lymphoblastic leukemia 33
adenocarcinoma 33
parvovirus 32
CEM 31
acute hepatitis 31
myopathy 30
Alpers 30
colon cancer 29
tumor progression 29
liver disease 29
retinoblastoma 28
ovarian cancer 28
HSV infection 27
neuroblastoma 27
malaria 26
WRN 26
lymphoblastic leukemia 26
MCF 26
lactic acidosis 24
mole 24
BLM 24
Alzheimer's disease 23
chronic myeloid leukemia 23
Leukemia 23
depression 22
pneumonia 22
latent infection 22
mole 22
Mycoplasma 22
mitochondrial disease 22
endometrial cancer 21
Burkitt's lymphoma 21
herpes zoster 21
avian sarcoma 21
fits 21
glioma 21
abortion 20
GSH 20
XPV 20
gastric cancer 19
premature aging 19
diabetes 19
ACV 19
prostate cancer 19
Hodgkin's disease 19
thalassemia 18
abdominal aortic aneurysm 18
AAA 18
avian leukosis 18
systemic lupus erythematosus 17
chronic liver disease 17
hepatitis A 16
peripheral neuropathy 16
renal disease 16
reticuloendotheliosis 16
CMV retinitis 16
dengue 16
APC 16
epilepsy 16
neurological disease 15
lung carcinoma 15
West 15
EBV infection 15
Fanconi 15
Gilbert 15
viral hepatitis 14
chronic persistent hepatitis 14
acute promyelocytic leukemia 14
acute leukemia 14
DDP 14
suicide 14
ischemia 14
Haemophilus 14
B virus infection 14
Marek's disease 14
genital herpes 13
lipodystrophy 13
thrombocytopenia 13
Parkinson's disease 13
Brown 13
Huntington's disease 13
mimicry 13
Cockayne syndrome 13
metastases 13
PML 12
cystic fibrosis 12
chronic lymphocytic leukemia 12
respiratory disease 12
Chronic hepatitis B 12
cervical cancer 12
non-small cell lung cancer 12
PHA 12
leishmaniasis 12
stroke 12
XPG 12
stomatitis 11
meningitis 11
retinitis 11
rash 11
Human immunodeficiency virus type 11
adenoma 11
mitochondrial myopathy 11
erythroleukemia 11
solid tumor 11
more...
Symptom
starvation 42
ophthalmoplegia 41
ataxia 40
collapse 25
diarrhea 25
fatigue 13
weakness 11
seizures 10
anorexia 10
nausea 10
dysarthria 9
vomiting 8
pain 7
headache 7
exhaustion 5
chills 5
cough 4
nasal discharge 4
lethargy 4
abdominal pain 4
agitation 3
penile lesion 3
Ill 3
Halo 3
hepatomegaly 3
hypothermia 3
neuralgia 3
respiratory distress 3
tremor 3
Ataxic 3
dyspnea 2
apathy 2
myalgia 2
hypotonia 2
nausea and vomiting 2
HSA 2
angina 2
night sweats 2
pallor 2
cerebellar ataxia 2
splenomegaly 2
Fluctuation 2
blepharospasm 2
tachypnea 1
skin irritation 1
neurological disability 1
emaciation 1
Spots 1
wheezing 1
neck pain 1
dark urine 1
abiotrophy 1
rhinorrhea 1
insomnia 1
spasticity 1
abdominal discomfort 1
hepatosplenomegaly 1
twitching 1
CSR 1
thinning 1
adenitis 1
spasm 1
chorea 1
eds 1
photophobia 1
No toxic effect 1
erythema 1
sore throat 1
hyperoxia 1
leg pain 1
autodigestion 1
incoordination 1
DNA marker 1
Sensory ataxia 1
hemoptysis 1
acidity 1
livedo 1
Drug
DNase I 95
lysine 92
-deoxyadenosine 59
Gel 58
Acyclovir 50
PFA 47
AZT 41
AZT 41
Dermatol 37
caffeine 34
Asn 33
Mutagen 31
HPMPC 29
Ganciclovir 26
PMEA 26
Cidofovir 25
Fragment 16
MRC 16
NH3 16
ascorbate 15
ampicillin 15
IL-2 14
Adriamycin 13
lactose 12
AC2 11
Alanine 11
Ara-A 11
CDP 10
BLM 10
Glycerol 10
MAP 9
ddI 9
Nephron 9
ROS 9
IFN-gamma 8
MgSO4 8
Entecavir 8
Entecavir 8
THF 8
ABC 8
Clofarabine 7
IFN-beta 7
PMPA 7
Leaf 7
NADH 6
TTC 6
Fraction 6
CTX 6
CSF 6
Zovirax 5
TAT 5
Biopolymers 5
AGG 5
pyridoxal phosphate 4
Deoxyadenosine 4
nitroglycerin 4
CaCl2 4
CaCl2 4
Cardiovasc 4
G418 4
CTT 4
Diamminedichloroplatinum 4
CaCl2 4
Neocarzinostatin 4
RFP 4
VCR 4
TAC 4
Pronase 4
ACT 3
EE2 3
ROX 3
ADR 3
Triclosan 3
FCV 3
Adefovir dipivoxil 3
2'-Deoxyadenosine 3
PCP 3
Meth 3
G-CSF 3
Alliance 3
VCR 3
ADM 3
Sulpiride 3
Telbivudine 3
Secretin 3
Itraconazole 2
vitamin E 2
FeCl3 2
Fludarabine 2
Bayer 2
Mycophenolic acid 2
AraC 2
Fluorescein 2
Histidinol 2
Aztec 2
Nephron 2
CoCl2 2
CoCl2 2
Kenyan 2
Mizoribine 2
Tenofovir 2
Arsenic trioxide 2
EFV 2
ZnO 2
KCL 2
Growth hormone 2
Oxaliplatin 2
Indomethacin 2
Prednisolone 2
p75 2
Myricetin 2
Monit 2
FAD 2
Growth hormone 2
PTC 2
Hepatitis B immune globulin 2
Gastro 2
FLP 2
Valganciclovir 2
Lobucavir 1
HCH 1
CTX 1
Bestatin 1
CTC 1
Reverset 1
Idarubicin 1
TFT 1
NVP 1
TiO2 1
PE2 1
BH4 1
TAK 1
Dihydro 1
CCL 1
Gold sodium thiomalate 1
Activin 1
Bifidobacterium 1
Ranitidine 1
Sorafenib 1
Irofulven 1
CTA 1
Solon 1
Vitamin K2 1
Desferal 1
Tacrolimus 1
Anthramycin 1
balanced salt solution 1
Sodium valproate 1
Foscavir 1
Artesunate 1
DMAP 1
Alovudine 1
Glycyrrhiza 1
Botox 1
MTC 1
Peridex 1
Adozelesin 1
ETS 1
CMX 1
Metrizamide 1
more...
Enzyme
DNA polymerase 17007
reverse transcriptase 1094
endonuclease 589
RNA polymerase 557
DNA ligase 418
DNA ligase 418
RNase H 345
thymidine kinase 344
DNase 239
topoisomerase 199
ATPase 198
topoisomerase 174
phosphodiesterase 159
RNase 153
ribonucleotide reductase 150
protein kinase 141
RNase 140
ribonucleotide reductase 135
thymidylate synthase 87
3'-exonuclease 84
transcriptase 78
S1 nuclease 72
dihydrofolate reductase 71
PARP 69
alkaline phosphatase 68
deoxyribonuclease 65
polynucleotide kinase 65
cdc2 55
alanine aminotransferase 53
deoxyribonuclease 51
ACS 50
luciferase 49
beta-galactosidase 45
glutathione S-transferase 44
TdT 42
trypsin 41
ribonuclease 40
ribonuclease 39
thymidylate kinase 38
micrococcal nuclease 36
peroxidase 32
catalase 30
chloramphenicol acetyltransferase 29
deoxycytidine kinase 29
AP lyase 27
proteasome 27
IMP dehydrogenase 26
superoxide dismutase 26
protein kinase C 26
mitogen-activated protein kinase 25
Escherichia coli exonuclease III 25
ERK 24
lambda exonuclease 24
exonuclease I 23
ornithine decarboxylase 21
lysozyme 21
caspase-3 21
proteinase K 21
endodeoxyribonuclease 20
dUTPase 20
venom phosphodiesterase 20
APC 19
DNA methyltransferase 18
deaminase 17
poly(A) polymerase 16
dCMP deaminase 16
factor C 16
aspartate aminotransferase 15
beta-lactamase 15
thymidine phosphorylase 14
adenosine deaminase 14
adenosine deaminase 14
glyceraldehyde-3-phosphate dehydrogenase 14
lactate dehydrogenase 14
STR 14
LexA repressor 14
hypoxanthine-guanine phosphoribosyltransferase 13
calcineurin 13
exonuclease V 13
3'-phosphatase 13
subtilisin 12
focal adhesion kinase 12
glyceraldehyde-3-phosphate dehydrogenase 12
glyceraldehyde-3-phosphate dehydrogenase 11
glyceraldehyde-3-phosphate dehydrogenase 11
exodeoxyribonuclease 11
glyceraldehyde-3-phosphate dehydrogenase 11
cytochrome oxidase 11
thioredoxin reductase 10
endonuclease V 10
triphosphatase 10
Fpg protein 10
glutathione peroxidase 10
PRE 10
acid phosphatase 10
complex I 9
exonuclease VII 9
PDE 9
pyruvate kinase 9
phospholipase C 9
guanylate kinase 8
P-glycoprotein 8
aspartate transcarbamylase 8
neuraminidase 8
exoribonuclease 8
demethylase 8
RNase D 8
RNase T1 8
tyrosinase 8
pyruvate dehydrogenase 7
TGT 7
glucose-6-phosphate dehydrogenase 7
adenylate kinase 7
deoxycytidine deaminase 7
dCMP hydroxymethylase 7
nucleoside diphosphokinase 7
phosphoglycerate kinase 7
DNase V 6
endonuclease VII 6
gamma-glutamyl transpeptidase 6
cytidine deaminase 6
lipase 6
purine nucleoside phosphorylase 6
firefly luciferase 6
succinate dehydrogenase 6
AMPK 6
chaperonin 6
HIV-1 protease 6
pyruvate dehydrogenase 6
pyruvate dehydrogenase 6
deoxyguanosine kinase 6
AGT 5
alpha-amylase 5
CPT 5
CPT 5
UmuD protein 5
CGT 5
thrombin 5
MEK 5
adenylate cyclase 5
dTTPase 5
lysin 5
CPS 5
AST 5
RNA ligase 5
ATP sulfurylase 5
creatine kinase 5
CPT 5
uridine kinase 5
5'-nucleotidase 5
ATP synthase 5
DNA 3'-phosphatase 5
TAT 5
hexokinase 5
polynucleotide phosphorylase 5
tissue plasminogen activator 4
DNase II 4
orotidine-5'-phosphate decarboxylase 4
RNase III 4
RNase P 4
more...
Compound
DNA 12811
Dec 1209
ATP 607
TTP 546
phosphate 468
dATP 455
dCTP 429
dGTP 386
pyrimidine 351
pyrimidine 351
hydrogen 321
Mg2+ 282
salt 271
manganese 238
oxygen 232
Clin 228
sodium 214
DAMP 203
alanine 191
sulfate 189
water 181
TMP 179
DEAE 172
dUTP 164
dCMP 164
glycerol 156
lysine 156
PPA 148
tyrosine 141
arginine 137
phosphonoacetic acid 131
methyl methanesulfonate 119
dGMP 112
Guo 111
bromide 111
Asp 108
His 108
SDS 107
ADP 103
Aphidicolin 102
Aphidicolin 102
pyrene 101
zinc 98
ADP 97
ADP 97
Phe 94
leucine 92
methionine 90
ammonium 90
CTP 88
GTP 84
serine 82
acetate 73
MgCl2 72
cysteine 71
urea 67
NH2 67
calcium 65
Adenine 65
AMP 65
threonine 59
uridine 59
Gly 57
potassium 55
nitrogen 54
ethanol 53
AZT 52
3TC 50
ACS 50
ACS 50
Acyclovir 48
ADP-ribose 48
copper 46
Ile 46
tryptophan 46
PPi 44
UTP 44
iron 42
PEG 41
NAD 40
EDTA 39
EDTA 39
dUMP 38
Ara-C 38
Tris 37
acrylamide 37
THF 37
Triton X-100 35
Optimal 35
tryptophan 34
caffeine 34
aldehyde 34
Tris 33
HCl 33
tryptophan 33
tryptophan 33
aldehyde 32
glucose 32
aspartic acid 29
silver 29
AAF 29
toluene 29
Foscarnet 29
aspartic acid 28
aspartic acid 28
aspartic acid 28
NAD 28
glutamate 27
DDP 26
galactose 26
pyridine 25
acridine 25
vinyl 25
H2O2 25
PMEA 25
TOF 24
BLM 24
methanol 24
adenylate 24
proline 24
valine 24
phosphorus 24
Cidofovir 24
glutamine 23
PEG 23
ammonia 23
TMP 22
PMA 22
Ara-C 22
A 3 21
methane 21
glutamic acid 21
3-aminobenzamide 21
TMP 21
phenol 21
nickel 21
TMP 21
Pac 21
chromium 20
Lac 20
fluorine 20
GSH 20
GSH 20
DMSO 20
PRPP 19
deoxyribose-5-phosphate 19
hydroxylamine 19
Thymidine 19
AAA 18
asparagine 18
Uracil 18
EMS 18
cAMP 18
8-OHdG 18
piperidine 17
Adriamycin 17
hydroxide 17
isoleucine 17
Ara-A 17
guanidine 17
more...