Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.7 (DNA polymerase)
 17,007 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Virally induced DNA polymerases have been demonstrated in cells infected with a variety of herpesviruses. These include herpes simplex virus (Weissbach et al., 1973), Marek's disease virus (Boezi et al., 1974), equine herpesvirus (Allen et al., 1977), and cytomegalovirus (Huang, 1975a). Recently a new iododeoxyuridine (IUDR)-induced intracellular DNA polymerase in an Epstein-Barr virus (EBV)-producing hybrid cell line has also been reported (Miller et al., 1977). We present evidence that there are two different DNA polymerase activities associated with EBV, one intracellular and the other virion-associated. Both of these enzymes have certain biochemical characteristics which distinguish them from each other, and from the host-cell DNA polymerases found in lymphocytes.
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PMID:Identification and partial purification of two EBV-associated DNA polymerases. 22 45

Idoxuridine which was first used in 1960 (Kaufman et al., 1962), has been for many years the only antiviral agent available in the treatment of herpetic keratitis. It is however no more successful than is mechanical removal of diseased epithelium (Patterson & Jones, 1967), and furthermore it may give rise to serious toxic side effects. The search for an alternative medication is therefore a pressing one. Trifluorothymidine (F3T) has, in recent years, been shown to be more effective than IDU and to be free from significant toxicity. Both of these drugs are pyrimidine nucleosides. Adenine Arabinoside or Arabinoside-A (Ara-A) is, by contrast, a purine nucleoside. It is thought to exert its antiviral effect by blocking DNA polymerase and ribonucleotide reductase.
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PMID:Treatment of herpetic keratitis. 41 44