Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.7 (
DNA polymerase
)
17,007
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The incorporation of labeled precursors into DNA, RNA and protein in phytohaemagglutinin (PHA)-prestimulated human lymphocytes was maximally inhibited by liver extract (LEx) or
arginase
at 24 h. The activities of
DNA polymerase alpha
, beta and gamma were less inhibitable by these agents than was [3H]thymidine incorporation. The inhibition of DNA, RNA and protein syntheses by either LEx or
arginase
is probably due to arginine depletion by
arginase
activity, since their syntheses were similarly inhibited when cultured in an arginine-free medium in the absence of
arginase
. These results indicate that
arginase
nonspecifically inhibits the activities of
DNA polymerase
. The inhibition is probably due to arginine depletion.
...
PMID:The mechanisms of the inhibitory effects of liver extract on lymphocyte proliferation. III. The effects of arginase on DNA polymerase activities. 247 98
