Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.7 (
DNA polymerase
)
17,007
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We examined the relationship between proliferative activity determined by
DNA polymerase alpha
and clinicopathologic variables in breast cancer patients, and evaluated the usefulness of
DNA polymerase alpha
as a prognostic predictor in 337 early breast cancers with tumors smaller than 2 cm, which had favorable outcomes. About 60% of tumors had lower proliferative activity. A significant correlationwas found between
DNA polymerase alpha
and ER, PgR, histological type, or the degree of infiltration into
lymphatic vessels
which reflect the prognosis. Cancers with higher
DNA polymerase alpha
activity were associated with shorter disease-free and overall survival times. In a multivariate analysis the
DNA polymerase alpha
was found to be an independent and significant factor in early breast cancer.
...
PMID:An Evaluation of DNA Polymerase alpha as a Prognostic Predictor in Early Breast Cancers Smaller than 2 cm. 1109 31
