Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.7 (
DNA polymerase
)
17,007
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In the
epididymis
of young rats, activities of DNA polymerases alpha, beta and gamma and DNA topoisomerase I decreased after castration.
DNA polymerase alpha
and gamma increased with androgen administration and activity reached 81.3% and 78.0%, respectively, of the activity in the sham-operated group on day 21. Activity of
DNA polymerase beta
remained at the activity of day 7 during androgen administration and was almost the same as that in the sham-operated group on day 21. DNA topoisomerase I activity showed a slight increase with androgen administration and reached 50.3% of that in the sham-operated group. The activities of these enzymes were not fully restored to those in the sham-operated group. These results indicate that in young rats activities of epididymal
DNA polymerase alpha
and gamma and DNA topoisomerase I are partially, and that of
DNA polymerase beta
wholly, dependent on androgens and may provide a means of investigating the regulation of epididymal cell proliferation.
...
PMID:Androgenic regulation of enzymes involved in DNA synthesis in epididymis of young rats. 133 37
