Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.7 (DNA polymerase)
 17,007 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chemotherapy against protozoan diseases has been practised since ancient times. Although still widely used, antiparasitic drugs are seldom completely effective. Complete elimination of an extensive protozoan infection usually requires a combination of drugs which target parasitic mechanisms very similar to the human host, as manifested by a multitude of side effects of varying severity. Furthermore, there is an escalating problem of widespread resistance to commonly used chemotherapeutic agents. Here we present an alternative strategy for the design of antiprotozoal agents using the principal enzyme involved in DNA replication as a possible drug target--DNA polymerase.
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PMID:Scientific hypothesis: a new strategy for the design of anti-protozoal drugs--DNA polymerase as a drug target. 795 92