Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.6 (
RNA polymerase
)
34,946
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We report identification and characterization of
Kv6.3
, a novel member of the voltage-gated K(+) channel. Reverse
transcriptase
-polymerase chain reaction analysis indicated that
Kv6.3
was highly expressed in the brain. Electrophysiological studies indicated that homomultimeric
Kv6.3
did not yield a functional voltage-gated ion channel. When
Kv6.3
and Kv2.1 were co-expressed, the heteromultimeric channels displayed the decreased rate of deactivation compared to the homomultimeric Kv2.1 channels. Immunoprecipitation studies indicated that
Kv6.3
bound with Kv2.1 in co-transfected cells. These results indicate that
Kv6.3
is a novel member of the voltage-gated K(+) channel which functions as a modulatory subunit.
...
PMID:Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. 1185 86
