Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.6 (
RNA polymerase
)
34,946
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Resistomycin
preferentially inhibits RNA synthesis in comparison to DNA and protein synthesis in intact bacterial cells. Studies with cell-free systems have shown that the antibiotic interferes with DNA and RNA synthesis, while protein synthesis is inhibited to a much lesser extent. Detailed studies in cell-free systems indicate an interaction of resistomycin with DNA- and
RNA polymerase
. In the case of
RNA polymerase
this was proved by CD measurements, whereas no interaction of the antibiotic with DNA, RNA, and homopolynucleotides could be found. One can conclude that the binding of the antibiotic to
RNA polymerase
is the basis for its interference with RNA synthesis.
...
PMID:Effects of the antibiotic resistomycin on the synthesis of macromolecules. 81 70
