Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.6 (
RNA polymerase
)
34,946
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Since 1984, unheated porcine clotting factor VIII (
Hyate:C
) has been used to treat severe bleeding episodes in persons with hemophilia who have antibodies to human clotting factor. We document the presence of porcine endogenous retrovirus (PERV) in plasma samples of pigs and in clinical lots of
Hyate:C
. Both gag and pol PERV RNA sequences were detected by reverse-
transcriptase
(RT) polymerase chain reaction in 13 of 13 lots of
Hyate:C
tested. Among 10 of these lots, RT activity also was detected, which confirms the presence of retroviral particles. To assess the transmission of PERV to
Hyate:C
recipients, we tested serum specimens from 88 recipients of
Hyate:C
and 23 noninfused control subjects for anti-PERV antibodies by using a Western blot assay. None of the samples was positive. Our data document that PERV particles are a common contaminant of
Hyate:C
products and suggest that the risk of PERV transmission from these percutaneous exposures is very low.
...
PMID:Evidence of porcine endogenous retroviruses in porcine factor VIII and evaluation of transmission to recipients with hemophilia. 1117 Sep 92
