Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.6 (
RNA polymerase
)
34,946
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The influenza A virus polymerase associates with a number of cellular transcription-related factors, including
RNA polymerase II
. We previously described the interaction of influenza virus polymerase subunit PA with human
CLE
/C14orf166 protein (hCLE), a positive modulator of this cellular
RNA polymerase
. Here, we show that hCLE also interacts with the influenza virus polymerase complex and colocalizes with viral ribonucleoproteins. Silencing of hCLE causes reduction of viral polymerase activity, viral RNA transcription and replication, virus titer, and viral particle production. Altogether, these findings indicate that the cellular transcription factor hCLE is an important protein for influenza virus replication.
...
PMID:Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication. 2190 Jan 57
