Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.6 (
RNA polymerase
)
34,946
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Reproductive barriers are commonly observed in both animals and plants, in which they maintain species integrity and contribute to speciation. This report shows that a combination of loss-of-function alleles at two duplicated loci,
DUPLICATED GAMETOPHYTIC STERILITY 1
(
DGS1
) on chromosome 4 and
DGS2
on chromosome 7, causes pollen sterility in hybrid progeny derived from an interspecific cross between cultivated rice,
Oryza sativa
, and an Asian annual wild rice,
O. nivara
Male gametes carrying the
DGS1
allele from
O. nivara
(
DGS1-nivara
s
) and the
DGS2
allele from
O. sativa
(
DGS2
-T65
s
) were sterile, but female gametes carrying the same genotype were fertile. We isolated the causal gene, which encodes a protein homologous to
DNA-dependent RNA polymerase
(RNAP) III subunit C4 (RPC4). RPC4 facilitates the transcription of 5S rRNAs and tRNAs. The loss-of-function alleles at
DGS1-nivara
s
and
DGS2
-T65
s
were caused by weak or nonexpression of
RPC4
and an absence of
RPC4
, respectively. Phylogenetic analysis demonstrated that gene duplication of
RPC4
at
DGS1
and
DGS2
was a recent event that occurred after divergence of the ancestral population of
Oryza
from other Poaceae or during diversification of AA-genome species.
...
PMID:Duplication and Loss of Function of Genes Encoding RNA Polymerase III Subunit C4 Causes Hybrid Incompatibility in Rice. 2859 58
