Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.6 (
RNA polymerase
)
34,946
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
It was discovered that alpha-tocopherol binding with isolated chromatin is specific only when fraction of tocopherol-binding proteins from a nuclear extract with 1% triton X-100 is present. During the chromatography of chromatin incubated with [H] alpha-tocopherol on hydroxyapatite a specific binding activity was present only in fraction eluted with 2M NaCl + 5M urea. Quantitative changes in the protein content of this fraction during a
hypovitaminosis
are found. It is shown that vitamin E can effect the
RNA polymerase
activity of a nuclear matrix in the in vitro assays. It is suggested that the presence of tocopherol-binding proteins of chromatin in necessary for such an action of alpha-tocopherol.
...
PMID:[Chromatin proteins binding vitamin E]. 797 44
The effect of vitamin B6 deficiency on the activity of
RNA polymerase
and expression of several mRNAs in rat liver was investigated. The activities of
RNA polymerase I
and II in the liver of vitamin B6-deficient rats were found to be higher than the control rats by 30%. The expression of several mRNAs, including mRNAs for beta-actin and glyceraldehyde-3-phosphate dehydrogenase, and the content of poly(A)+ RNA were also increased in
vitamin deficiency
. These observations suggest that vitamin B6 influences gene expression in the liver, at least in part, by modulating the activity of
RNA polymerase
.
...
PMID:Vitamin B6 deficiency causes activation of RNA polymerase and general enhancement of gene expression in rat liver. 840 98
