Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.6 (RNA polymerase)
34,946 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pausing of RNA polymerase II (RNAPII) at the 5' end of genes is a widespread phenomenon in metazoans, but the role of this event in gene regulation is poorly understood. Gilchrist et al. (2010) now demonstrate that RNAPII pausing counteracts DNA-influenced nucleosome organization to allow precise gene activation.
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PMID:The meaning of pausing. 2107 46