Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.49 (reverse transcriptase)
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Human Gene/Protein
BPTP-2 10.0
myelodysplasia/myeloid leukemia factor 2 10.0
TAO kinase 3 10.0
TRGV3 10.0
VL6 10.0
MLL/ENL fusion protein 10.0
translational release factor 1 10.0
Ribosomal protein S26 10.0
CYB5D1 10.0
NKAT9 10.0
trithorax homolog, Drosophila 10.0
SLC25A5 protein 10.0
Syntaxin 3A 10.0
GIG10 10.0
CGI-140 10.0
MLL/GAS7 10.0
WD repeat domain 59 10.0
DNA helicase homolog 10.0
ADAM metallopeptidase domain 29 10.0
dystrophia myotonica-containing WD repeat motif 10.0
WFDC10A 10.0
SH3 and multiple ankyrin repeat domains 2 isoform 2 10.0
COMM domain containing 3 10.0
GTF2H1 protein 10.0
KIAA0218 10.0
RGP4 10.0
SLC25A6 protein 10.0
hypothetical protein FLJ20343 10.0
apolipoprotein(a 10.0
ubiquitin-conjugating enzyme E2 D2 10.0
60S ribosome subunit biogenesis protein NIP7 homolog 10.0
ERVK6 10.0
H2B/S 10.0
RHBDL3 10.0
PEBP2B 10.0
EP2E 10.0
NCR3 protein 10.0
RNA-directed DNA polymerase 10.0
p66 RT 9.0
TRMT61A 9.0
DIRC1 9.0
C5orf17 9.0
suppression of tumorigenicity 7-like 9.0
three prime repair exonuclease 2 9.0
XLKD1 9.0
GIG18 9.0
CGKII 9.0
large multifunctional peptidase 7 9.0
60S ribosomal protein L15 9.0
dedicator of cytokinesis 10 9.0
glycine/tyrosine-rich protein 9.0
LAMRL5 9.0
beta hENaC 9.0
FGF intracellular binding protein 9.0
Ets variant gene 6 9.0
epsin 3 9.0
RNF19 9.0
UAP1L1 9.0
CLK/STY 9.0
40S ribosomal protein S3a 9.0
alpha-methyl-acyl-CoA racemase 9.0
orf 2 9.0
CBP/MOZ 9.0
patatin-like phospholipase domain containing 8 9.0
GMFB protein 9.0
SLC7A6OS 9.0
FYN protein 9.0
LIM-1 9.0
ALL-1/AF-4 9.0
Bcl-2-related ovarian killer protein 9.0
alpha-(1,3)-fucosyltransferase 9.0
GLUL protein 9.0
schwannomin-interacting protein 1 9.0
DSCR1 protein 9.0
DNA-directed DNA polymerase 8.8
p66 8.8
DNA-dependent DNA polymerase 8.8
XPCC 8.7
putative reverse transcriptase 8.7
GLYT-1 8.6
more...
Disease
HC/HCC 10.0
Parotid lipomatosis 9.0
Atrophy of thymus 8.6
myeloblastosis 8.4
ALKoma 8.4
Acute ulcerative colitis 8.0
Fat redistribution 7.8
Viral respiratory infection 7.6
GABEB 7.4
Anemic hypoxia 7.2
Lipodermatosclerosis 7.2
Boid inclusion body disease 7.2
Ischemic cerebral infarction 7.2
stage III endometrial cancer 7.2
Pleomorphic malignant fibrous histiocytoma 7.0
DFNA17 6.8
hyperthyroid heart disease 6.8
Human immunodeficiency virus type 6.7
IGCNU 6.6
ATCAY 6.6
FTC 6.5
VMCM 6.5
SPG21 6.4
EBS2 6.4
lipoatrophy 6.4
Visna 6.3
SYNDROMES 6.3
Chronic Chagas' disease 6.3
stage III cervical cancer 6.3
Turkey rhinotracheitis 6.3
Synovial Sarcoma 6.3
X-linked alpha-thalassemia/mental retardation syndrome 6.2
Thoracic Disease 6.2
Enterovirus infection 6.1
Rhodesian sleeping sickness 6.1
Dedifferentiated chondrosarcoma 6.1
recurrent retinoblastoma 6.1
Congenital methemoglobinemia 6.1
Autoimmune myocarditis 6.1
Annular erythema 6.1
alpha-Mannosidosis 6.1
Feline Leukemia 6.1
FAIDS 6.0
hepatitis G 6.0
Clear cell sarcoma of tendons and aponeuroses 6.0
Small cell osteosarcoma 6.0
EBS1 5.9
avian sarcoma 5.9
Granulomatous disease 5.9
Lorain 5.9
Lipohypertrophy 5.9
Adult periodontitis 5.9
Vaccinia virus infection 5.9
HIV-2 infection 5.9
lipodystrophy 5.9
Fanconi-like syndrome 5.8
Singleton-Merten syndrome 5.8
Infantile malignant osteopetrosis 5.8
Proximal renal tubular acidosis 5.8
RP13 5.8
avian leukosis/sarcoma 5.8
Mitochondrial DNA depletion 5.8
adult APL 5.8
Ph- CML 5.8
La Crosse encephalitis 5.8
immunodeficiency 5.7
Congenital ichthyosiform erythroderma 5.7
APL differentiation syndrome 5.7
Cognitive deterioration 5.6
CMCT 5.6
Progression of prostate cancer 5.6
pediatric APL 5.6
ZD1 5.6
Leukemia relapse 5.6
HIV 5.5
Equine influenza 5.5
CEM 5.5
avian leukosis 5.5
peripheral primitive neuroectodermal tumor 5.4
Andermann syndrome 5.4
more...
Symptom
Asymptomatic hyperlactatemia 10.0
Opiate withdrawal symptoms 8.4
CNS symptom 7.6
Tissue anoxia 7.6
Koplik spots 6.2
musculoskeletal chest pain 6.0
enanthema 5.3
astasia 4.0
staggering gait 3.8
No toxic effect 3.6
skin irritant 3.4
respiratory problem 3.3
phosphatemia 3.2
Crushing 3.0
chromosome marker 2.8
generalized rash 2.8
nasal discharge 2.7
Neurologic symptoms 2.4
emaciation 2.2
disturbed balance 2.1
Respiratory symptoms 2.1
non-productive cough 1.8
dark urine 1.8
myalgia 1.7
No adverse effect 1.6
meningism 1.6
splenomegaly 1.6
abdominal discomfort 1.5
bitter taste 1.5
eds 1.5
Hudson 1.5
rhinorrhea 1.4
anosmia 1.4
photophobia 1.3
diarrhea 1.3
torticollis 1.3
abdominal fullness 1.3
belching 1.3
asthenia 1.2
incoordination 1.2
sore throat 1.1
DNA marker 1.1
wheezing 1.1
starvation 1.1
hepatosplenomegaly 1.0
HSA 1.0
rundown 1.0
pallor 1.0
tachypnea 1.0
dizziness 1.0
nausea 1.0
lethargy 1.0
POA 0.9
adenitis 0.8
nasal congestion 0.8
decreased appetite 0.8
cough 0.8
arthralgia 0.7
neck stiffness 0.7
respiratory distress 0.7
sneezing 0.7
rales 0.6
anorexia 0.5
CSR 0.5
Neuropathic pain 0.5
Ill 0.3
renal colic 0.3
rigors 0.3
hepatomegaly 0.3
vomiting 0.2
clubbing 0.2
muscle cramps 0.1
flushing 0.1
paraparesis 0.1
dystonia 0.1
orofacial pain 0.1
twitching -0.0
blepharospasm -0.0
blurred vision -0.0
insomnia -0.1
more...
Drug
Atevirdine mesylate 10.0
C19H16O5 10.0
Reverset 9.8
Rescriptor 9.4
Etravirine 9.4
Loviride 9.0
Emivirine 9.0
Senega 9.0
Amdoxovir 8.6
EFV 8.5
Prezista 8.4
Lexiva 8.4
Brecanavir 8.4
Capravirine 8.4
Alovudine 8.4
Desciclovir 8.4
Truvada 8.2
Fosamprenavir 8.0
ddI 8.0
Tenofovir disoproxil fumarate 7.9
AZT 7.7
Tenofovir 7.7
PMPA 7.7
Epivir 7.6
AZT 7.6
TMC114 7.5
Lexatumumab 7.4
Ziagen 7.4
Fosamprenavir calcium 7.3
Lobucavir 7.2
Mecasermin rinfabate 7.2
Viracept 7.0
Lobenzarit disodium 7.0
Adefovir dipivoxil 7.0
Agenerase 6.8
Buserelin acetate 6.8
Aztec 6.8
Truvada 6.7
Enfuvirtide 6.7
Raltegravir 6.7
Elvitegravir 6.6
Crixivan 6.6
NLF 6.6
Crixivan 6.6
Invirase 6.4
Crixivan 6.4
7-Methylguanosine 6.4
PMEA 6.3
URF 6.3
Entecavir 6.2
Entecavir 6.2
Atazanavir sulfate 6.2
Indinavir 6.1
Isosulfan blue 6.1
Norvir 6.1
NVP 6.0
Kaletra 5.9
Darunavir 5.9
Calamine 5.9
Argininosuccinate 5.9
ATV 5.8
Onon 5.8
SPP 5.7
Accolate 5.7
Clevudine 5.4
TPV 5.4
Fluspirilene 5.3
TEL 5.3
Maraviroc 5.2
ULR 5.2
Diphtheria toxoid 5.2
PFA 5.1
Norleucine 5.1
Nelarabine 5.0
Gamma-Aminobutyric acid 4.8
Ilomastat 4.7
Pleconaril 4.6
RAL 4.6
Diclazuril 4.5
Wellferon 4.5
more...
Enzyme
reverse transcriptase 10.0
exoribonuclease H 9.0
acetylpyruvate hydrolase 9.0
3alpha(17beta)-HSD 9.0
EC 2.3.1.156 9.0
RNase H 8.4
CYP12 7.4
RNA cyclase 7.2
hydroxylaminobenzene mutase 7.0
glyoxylate dehydrogenase 7.0
EC 1.1.1.219 6.8
EC 2.4.1.214 6.8
HIV-1 protease 6.7
matrilysin-2 6.6
(+)-delta-cadinene synthase 6.6
Metallocarboxypeptidase D 6.6
naphthalene dihydrodiol dehydrogenase 6.6
UDP-glucuronate decarboxylase 6.4
coronavirus main proteinase 6.3
cathepsin B-like protease 6.2
kallikrein 10 6.2
ARD' 6.1
DNA polymerase 6.0
glucosaminyl 3-O-sulfotransferase 6.0
glucosaminyl 3-O-sulfotransferase 6.0
L-serine hydro-lyase 6.0
oxalyl-CoA decarboxylase 5.9
tetrachloroethene reductive dehalogenase 5.9
AO1 5.8
EC 2.4.2.26 5.6
CbiX 5.5
phosphatidylcholine synthase 5.5
RNase D 5.5
dUTPase 5.4
25-hydroxyvitamin D3 1alpha-hydroxylase 5.3
AAO3 5.2
alpha-1,4-glucan lyase 5.2
UDP-sugar pyrophosphorylase 5.2
transcriptase 5.1
deoxycytidine deaminase 5.1
S-formylglutathione hydrolase 5.1
protein acyltransferase 5.1
muconolactone isomerase 5.1
phenylacetyl-CoA ligase 5.0
homospermidine synthase 5.0
methylmalonyl-CoA epimerase 5.0
FGAM synthetase 5.0
EC 3.6.1.17 4.9
deoxycytidine kinase 4.9
cyanide hydratase 4.9
gentisate 1,2-dioxygenase 4.9
lysyl-tRNA synthetase 4.9
atrazine chlorohydrolase 4.8
thymidylate kinase 4.8
exonuclease VII 4.8
ent-copalyl diphosphate synthase 4.8
caspase-5 4.7
stratum corneum chymotryptic enzyme 4.7
3-hydroxy-3-methylglutaryl-CoA lyase 4.7
Escherichia coli exonuclease III 4.7
ATase 4.6
poly(A)-specific ribonuclease 4.6
tryptophan aminotransferase 4.6
acyloxyacyl hydrolase 4.6
VIP1 4.6
granzyme K 4.5
thiosulfate dehydrogenase 4.5
inositol polyphosphate kinase 4.5
fructan exohydrolase 4.5
polynucleotide kinase 4.5
galactolipase 4.5
ABA2 4.5
PRT 4.5
endodeoxyribonuclease 4.5
polypeptide N-acetylgalactosaminyltransferase 4.4
protein N-myristoyltransferase 4.4
caspase-5 4.4
bidirectional hydrogenase 4.4
maleylacetate reductase 4.4
1-acylglycerol-3-phosphate O-acyltransferase 4.4
more...
Compound
C19H16O5 10.0
C19H16O5 10.0
C19H16O5 10.0
5,6-quinolinedione 10.0
C19H16O5 10.0
C19H16O5 10.0
C19H16O5 10.0
C19H16O5 10.0
C19H16O5 10.0
Delavirdine mesylate 9.6
ethylenesulfonic acid 9.4
1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine 9.4
ethylenesulfonic acid 9.4
Calanolide A 9.4
Delavirdine 9.2
2-Naphthalenesulfonic acid 9.0
3-amino-1,5-naphthalenedisulfonic acid 9.0
(2-bromoethyl)benzene 9.0
N-Methylisatin 9.0
Mollisin 9.0
Psychotrine 9.0
C19H16O5 9.0
Nevirapine 8.8
Efavirenz 8.7
Abacavir 8.5
4-Ethylresorcinol 8.4
4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 8.4
C19H20O6 8.4
Psychotrine 8.4
C19H20O6 8.4
C19H20O6 8.4
C19H20O6 8.4
C19H20O6 8.4
C19H20O6 8.4
Digallic acid 8.4
C19H16O5 8.4
C19H20O6 8.4
Sulfolithocholate 8.4
C19H20O6 8.4
C19H20O6 8.4
4-amino-5-hydroxy-2,7-naphthalenedisulfonic acid 8.4
C19H20O6 8.4
C19H20O6 8.4
Direct Yellow 50 8.4
C19H20O6 8.4
C19H20O6 8.4
d4T 8.3
Emtricitabine 8.1
C19H20O6 8.0
2,7-naphthalenedisulfonic acid 8.0
2,7-naphthalenedisulfonic acid 8.0
C19H20O6 8.0
4-tert-butylphenyl salicylate 8.0
Aureothin 8.0
2,7-naphthalenedisulfonic acid 8.0
Quinhydrone 8.0
Asterriquinone 8.0
C19H20O6 8.0
AF/ABDP 8.0
3TC 7.9
Didanosine 7.9
AZT 7.7
C19H20O6 7.6
C8H8O5 7.6
Ara-G 7.6
AF/ABDP 7.6
C8H8O5 7.6
Ara-G 7.6
C19H20O6 7.6
Pretazettine hydrochloride 7.6
C8H8O5 7.6
C8H8O5 7.6
C8H8O5 7.6
C8H8O5 7.6
C7H6N2 7.6
C8H8O5 7.6
Ethylmalonic acid 7.6
A 162 7.6
2-phenylpyrrolidine 7.6
Foscarnet sodium 7.4
more...