Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.49 (
reverse transcriptase
)
31,746
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
BACKGROUND In the present study, we aimed to investigate the prognostic value of
epithelial membrane protein 1
(
EMP-1
) gene in patients diagnosed with laryngeal carcinoma (LC). MATERIAL AND METHODS Patients who were pathologically diagnosed with LC were enrolled in the present study. The expression levels of
EMP-1
in tumor tissues and corresponding normal tissues collected from the LC patients were detected by semi-
reverse transcriptase
polymerase chain reaction (semi-RT-PCR). Chi-square analysis was used to evaluate the relationship between
EMP-1
expression level and clinical characteristics. Survival analysis for the study population was analyzed by Kaplan-Meier method with log rank test. Additionally, Cox regression model was applied to evaluate the prognostic value of
EMP-1
in LC patients. RESULTS 106 LC patients, including 55 men and 51 women, were enrolled in the present study. Semi-RT-PCR demonstrated that the expression level of
EMP-1
was decreased in tumor tissues, compared with adjacent normal tissues (p<0.001). Moreover, the level was significantly associated with lymph node metastasis, histological grade, and clinical stage (p<0.05 for all). In addition, low levels of
EMP-1
was significantly correlated with poor survival rate (log rank test, p=0.020). Cox regression analysis indicated that
EMP-1
was an independent marker for LC prognosis (HR=2.755, 95% CI=1.123-6.760, p=0.027). CONCLUSIONS The abnormal expression of
EMP-1
may be associated with progression of LC and the gene may act as a prognostic marker for LC.
...
PMID:The Prognostic Value of Epithelial Membrane Protein 1 (EMP-1) in Patients with Laryngeal Carcinoma. 2877 68
