Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.49 (reverse transcriptase)
 31,746 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

HIV-positive patients may experience erectile dysfunction and Viagra may be prescribed as a treatment. Viagra is processed by the P450 enzyme system and may negatively interact with other drugs, including protease inhibitors and non-nucleoside reverse transcriptase inhibitors (NNRTI). Protease inhibitors and delavirdine may increase Viagra levels and increase the risk of side effects. The NNRTIs efavirenz and nevirapine may lower levels of Viagra and reduce its effectiveness. The combination of Viagra with amyl nitrate can cause life-threatening drops in blood pressure.
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PMID:A note about Viagra. 1136 23