Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.49 (
reverse transcriptase
)
31,746
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Milk from a number of species (e.g., man, mouse, rat, dog, and cow) contains inhibitors of the
RNA-directed DNA polymerase
. When attempts are made to isolate virions from the milk, part of the inhibitors follow the virions in the purification. The amount of inhibitors varies in different milk samples. These inhibitors can probably account for the large discrepancies reported in studies of the presence of oncornaviruses in human milk. Phosphatases bound to subcellular particles or fragments seem to be the most important inhibitors in the milk interfering with the
RNA-directed DNA polymerase
assay. It is shown that the inhibitory enzymes can be completely removed by sedimentation of the milk through a
Metrizamide
gradient.
...
PMID:Removal of inhibitors against RNA-directed DNA polymerase activity in human milk. 5 90
