Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.7.49 (reverse transcriptase)
 31,746 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Acyclovir is an effective drug for the treatment of HSV and VZV infections, which after phosphorylation to the triphosphate, inhibits viral DNA polymerase. Acyclovir has low oral bioavailability, therefore prodrugs have been developed, and the L-valyl ester, valaciclovir, recently has been licensed for the treatment of shingles. Ganciclovir is used against CMV, and famciclovir, a lipophilic prodrug of penciclovir, is marketed for shingles. The acyclic nucleoside phosphonates are active against thymidine kinase-resistant viral strains. Promising analogs are PMEA (in clinical trial for the treatment of AIDS) and (S)-HPMPC (good in vivo activity against HSV, VZV, CMV, and EBV). Oligonucleotides incorporating acyclic nucleosides at the 3'-and 5'-ends, or constituted of amino acyclic nucleosides, are resistant to cleavage by nucleases and may be useful in antisense and/or antigene therapy. HEPT is active against HIV-1: It binds in a hydrophic pocket on reverse transcriptase, rather than in the polymerase active site. Some acyclic nucleosides are potent inhibitors of purine and pyrimidine nucleoside phosphorylase. These compounds may have a therapeutic niche in combination therapy with antiviral and anticancer nucleosides, and in the treatment of diseases involving the T-cell.
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PMID:Acyclic nucleosides as antiviral compounds. 873 25

Information about protease inhibitors and other antiretroviral drugs used to treat AIDS-related opportunistic infections is provided. Specific drugs addressed include ritonavir, a protease inhibitor that received the fastest approval in history, for HIV infection; Vitrasert, an intraocular form of ganciclovir, for treating CMV retinitis; 3TC, an antiviral agent for treating HIV infection; a combination of saquinavir and ritonavir for treating HIV infection; nevirapine, a reverse transcriptase inhibitor for HIV infection; nitazoxanide, available through an FDA-approved expanded access program, for cryptosporidiosis; indinavir, an HIV protease inhibitor used for HIV infection; and a combination of ddC and AZT for HIV infection.
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PMID:[New treatments for HIV]. 1136 30