Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.49 (
reverse transcriptase
)
31,746
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The mRNA expression of human
UDP-glucuronosyltransferase 1A8
(
UGT1A8
) has been found in jejunum, ileum, and colon but not in liver. A cDNA with a complete
UGT1A8
coding region was amplified from total human ileal RNA by
reverse transcriptase
-polymerase chain reaction and inserted into the mammalian expression vector, pcDNA3. Lysates of HK293 cells expressing
UGT1A8
revealed the expression of a protein with a molecular mass of 56 kDa by Western blot analysis. Transiently expressed human
UGT1A8
shows glucuronidation activities with coumarins, anthraquinones, flavonoids, phenolic compounds, catechol estrogens, 17-hydroxyandrogens, primary amines such as the carcinogen 4-aminobiphenyl, and certain opioids. This UGT may play an important role in the detoxification of xenobiotics in human intestine.
...
PMID:Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8. 970 21
