Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.49 (
reverse transcriptase
)
31,746
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Gastric carcinoma is the most common neoplasm in Southeast Asian populations and is the second leading cause of cancer death worldwide. Annexins are a family of cytosolic calcium and membrane binding proteins that have been implicated in a wide variety of cell functions. Recent studies have suggested that
Annexin A10
(
ANXA10
), a member of the Annexin protein family, is down-regulated in specific types of cancer. However, the underlying molecular mechanisms of the dysregulation of
ANXA10
remain to be elucidated. In the present study, to investigate the biological effects of
ANXA10
on gastric carcinoma, aberrant expression of
ANXA10
was evaluated by Western blot analysis,
reverse transcriptase
-polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC), in gastric cancer tissues and cell lines. Decreased expression of
ANXA10
was observed in five selected gastric cancer tissues compared to the normal surrounding mucosa. In the cancer cell lines, seven out of nine selected gastric cancer cell lines had no detectable
ANXA10
by RT-PCR. Among these, when an
ANXA10
expressing plasmid was introduced into MKN-1 cells, cell growth was suppressed and apoptosis augmented. The results of this study demonstrated that
ANXA10
was aberrantly regulated in gastric carcinoma and suggests that down-regulation of
ANXA10
might be involved in gastric carcinogenesis. In addition,
ANXA10
may play a role, as a tumor suppressor, in the development and progression of gastric cancer.
...
PMID:Decreased expression of annexin A10 in gastric cancer and its overexpression in tumor cell growth suppression. 2066 64
