Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.48 (
transcriptase
)
9,479
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A key protein in the production and in the maintenance of the endocochlear potential is the Na,K-ATPase. Previously, we have shown that
FXYD6
is a modulator of the Na,K-ATPase expressed in the inner ear (Delprat et al. [2007] J Biol Chem 282:7450-7456). To investigate the potential role of
FXYD6
in inner ear function, we studied the developmental expression of
FXYD6
. Reverse
transcriptase
-polymerase chain reaction analysis demonstrates that
FXYD6
is present as two splice variants. Both variants coimmunoprecipitate with Na,K-ATPase after expression in Xenopus oocytes. Immunohistochemistry of the cochlea (from birth to postnatal day 30) shows that
FXYD6
is expressed in several epithelial cells important for endolymph homeostasis. Marked similarities were found in the developmental expression patterns of
FXYD6
and Na,K-ATPase, suggesting functional cooperation between the two proteins in the generation and maintenance of the endocochlear potential and ion composition of the endolymph.
...
PMID:Dynamic expression of FXYD6 in the inner ear suggests a role of the protein in endolymph homeostasis and neuronal activity. 1767 40
