Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.48 (
transcriptase
)
9,479
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Early detection of ovarian cancer is difficult owing to the lack of specific and sensitive tests available. Previously, we found expression of
nectin 4
to be increased in ovarian cancer compared with normal ovaries. Reverse
transcriptase
-polymerase chain reaction (RT-PCR) and quantitative RT-PCR validated the overexpression of
nectin 4
messenger RNA in ovarian cancer compared with normal ovarian cell lines and tissues. Protein levels of
nectin 4
were elevated in ovarian cancer cell lines and tissue compared with normal ovarian cell lines as demonstrated by Western immunoblotting, flow cytometry, and immunohistochemical staining of tissue microarray slides. Cleaved
nectin 4
was detectable in a number of patient serum samples by enzyme-linked immunosorbent assay. In patients with benign gynecologic diseases with high serum CA125 levels,
nectin 4
was not detected in the majority of cases, suggesting that
nectin 4
may serve as a potential biomarker that helps discriminate benign gynecologic diseases from ovarian cancer in a panel with CA125.
...
PMID:Nectin 4 overexpression in ovarian cancer tissues and serum: potential role as a serum biomarker. 2095 69
