Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.48 (
transcriptase
)
9,479
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Evidence suggests that nevirapine, a non-nucleoside reverse-
transcriptase
inhibitor, might be very effective in the prevention of HIV-1 integration and the reduction of risk of HIV-1 acquisition after exposure. We used a triple combination regimen, including nevirapine, for prophylaxis after occupational or sexual exposure to HIV-1 infection. Of 57 individuals who started therapy, only 41 returned for follow-up. Five had a grade three or four
drug-induced hepatitis
, two of whom also had a rash. This high rate of major adverse events raises concerns over the safety of such a regimen for its use in this population.
...
PMID:Prophylaxis with a nevirapine-containing triple regimen after exposure to HIV-1. 1151 14
