Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.7.48 (
transcriptase
)
9,479
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Tight junctions are composed of claudins, occludins, junctional adhesion molecules and plaque proteins. Claudin 2 protein forms a cation-selective channel which confers increased permeability in renal epithelial cells and in the intestine where its expression is restricted to the leaky epithelium. Immunohistochemical staining revealed
claudin 2
staining in the granular layer of adult epidermis. Analysis of Western blots revealed bands corresponding to the molecular weight of
claudin 2
in Madin-Darby canine kidney II cells, human kidney, adult skin and neonatal keratinocytes. Reverse
transcriptase
polymerase chain reaction on mRNA and cDNA sequence analysis found a 99% sequence homology between our cDNA and human
claudin 2
(NIH BLAST sequence). Further, we show that all-trans-retinoic acid increases the expression of
claudin 2
in keratinocytes in a dose-dependent manner. The discovery of
claudin 2
transcript and protein in the skin could be of importance in epidermal differentiation, barrier function and pathological conditions.
...
PMID:Claudin 2 mRNA and protein are present in human keratinocytes and may be regulated by all-trans-retinoic acid. 1850 55
