Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.13.3 (histidine kinase)
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Human Gene/Protein
DBX1 13.7
TMEM39B 13.7
HK1 13.7
RRG1 13.7
LOC400464 13.7
KIAA0746 12.7
branched chain alpha-ketoacid dehydrogenase kinase 12.7
HK3 12.2
TNFAIP2 protein 12.1
CDC42EP1 12.1
SYDE2 12.1
AK3L1 12.1
HK4 12.1
MFSD5 11.7
CDK5R2 11.7
PASKIN 11.5
ACTBL2 11.4
CDKL2 11.4
EPS8L2 11.4
HPT protein 11.4
HLR1 11.2
hexokinase 3 11.2
GAF1 11.1
FN3KRP 11.1
SLC25A23 11.1
CAF2 11.1
Bos1 11.0
HMG20B 10.9
HKR1 10.9
NKX2-6 10.9
Mak3p 10.5
kinase suppressor of ras 10.5
RCL1 10.5
MAN1A2 10.5
POTEE 10.5
HAMP 10.4
FNBP1L 10.4
PRKCDBP 10.4
MORC3 10.4
INHBC 10.4
SDF-2 10.1
CDC2L1 10.1
phosphohistidine phosphatase 10.1
DOK4 10.0
KLHL7 10.0
PPM2 10.0
PIK4CA 10.0
doublecortin kinase-2 9.9
STAC 9.8
CMT4C 9.8
RAPGEF3 9.8
HGN 9.8
EIF2S3 9.7
PABP-interacting protein 2 9.7
SLC2A8 9.6
FEM1B 9.6
CENP-Q 9.6
Spy1 9.6
SBF1 9.5
NPM3 9.5
HK2 9.5
OS4 9.5
Chp 9.5
AARS 9.4
THIK-2 9.4
TIG1 9.4
PSMC3 9.4
HADH 9.4
GLUT6 9.4
ATP5D 9.4
V-ATPase subunit A 9.3
PSMD1 9.3
RAB2A 9.3
hexokinase 1 9.3
TBCD 9.2
PFKP 9.2
KCNB1 9.2
SH3TC2 9.2
ARR1 9.2
HMGCL 9.2
FGD4 9.2
SPAG6 9.2
SLC6A6 9.1
EID1 9.1
DHTKD1 9.1
ALG8 9.1
ushA 9.0
GMP synthase 9.0
FMN2 9.0
GLUD1 9.0
KHK 9.0
RAB1A 9.0
RNF216 8.9
EIF2S1 8.9
ATP-dependent glucokinase 8.9
Sim 8.9
CNE1 8.9
SLC16A1 8.8
P76 8.8
GOT1 8.8
ALDOA 8.8
Histone H4 8.8
ALG2 8.8
ribosomal protein L6 8.8
SLC2A10 8.8
LASS2 8.7
MGB1 8.7
BPGM 8.7
GAF 8.7
TNFAIP2 8.7
PURA 8.7
PGAM1 8.7
MRAS 8.6
SMCHD1 8.6
Arnt 8.6
ALG6 8.6
SQLE 8.6
ENO2 8.6
Fructosamine-3-kinase 8.6
Barth syndrome 8.6
LAMR1 8.6
FOLH1 8.5
BAG2 8.5
porin 8.5
NAB1 8.5
PFKFB4 8.5
TPI1 8.5
TXNRD2 8.5
nucleoside diphosphate kinase 8.5
CIB 8.5
RARRES1 8.4
DPYSL2 8.4
GMP reductase 8.4
PSMA6 8.4
AKAP4 8.4
PDK3 8.4
EIF4G1 8.4
ARR2 8.4
TUBA1A 8.4
FAM3C 8.3
IL18R1 8.3
PRS I 8.3
metastasis suppressor protein 8.3
HPT1 8.3
ME3 8.3
Hexokinase 8.3
NDP kinase 8.3
PFKM 8.3
PRND 8.3
NCYM 8.3
hexokinase 2 8.3
CFL2 8.2
PKN1 8.2
GCK 8.2
Sorbitol dehydrogenase 8.2
ENO1 8.2
ATP synthase subunit beta 8.2
SLC2A5 8.2
DKK4 8.2
PMM2 8.2
more...
Disease
CMT4G 13.7
Hexokinase deficiency 13.7
CMT4D 12.0
CMT4C 10.4
Cyanotic congenital heart disease 9.6
trisomy 10p 9.6
TBCD 8.7
Nasopharyngeal carcinoma 7.7
Papillary renal cell carcinoma 7.5
CCA1 7.4
PCC 7.1
hereditary sensory neuropathy 6.9
Pemphigus foliaceus 6.7
Cohen syndrome 6.4
FHL2 6.3
gas gangrene 6.2
Papillomas 6.1
FALS 6.0
osteochondritis 5.9
Brucella abortus 5.8
pheochromocytoma 5.8
hereditary motor and sensory neuropathy 5.7
APOA1 5.6
PDC 5.6
crown gall 5.6
Silence 5.5
Giant cell tumor of bone 5.5
CAA 5.3
pneumonic plague 5.3
ERS 5.2
Liver regeneration 5.2
PER 5.1
FDH 5.0
bacillary dysentery 5.0
CAA 4.9
EPS 4.9
Brucella melitensis 4.9
hyperkeratosis 4.9
GBS 4.8
chemical carcinogenesis 4.8
community acquired pneumonia 4.8
CUP 4.8
EPS 4.7
ehrlichiosis 4.7
NPC 4.7
PHP 4.7
sporotrichosis 4.6
Mendelian disorders 4.6
profound mental retardation 4.6
lymphoepithelioma 4.4
AEM 4.4
familial hemophagocytic lymphohistiocytosis 4.4
urosepsis 4.3
Campylobacter infection 4.3
cholera 4.3
HIV disease progression 4.3
Yersinia 4.2
INS 4.2
RP4 4.2
Fox 4.2
MCS 4.2
papilloma 4.2
MCS 4.2
monocytic leukemia 4.1
systemic candidiasis 4.1
relapsing fever 4.1
CLN3 4.0
pseudotuberculosis 4.0
Bardet-Biedl syndrome 4.0
Legionella 3.9
rind 3.9
Lyme disease 3.9
RGS 3.9
bends 3.9
HTS 3.8
chancroid 3.8
musculoskeletal disease 3.8
Charcot-Marie-Tooth disease 3.7
melioidosis 3.7
keratosis 3.7
PAL 3.6
chlorosis 3.6
LDLR 3.6
FUS 3.5
Bordetella 3.4
laryngeal cancer 3.4
complex partial seizures 3.4
Malignancy 3.4
PIN 3.3
Mycobacterium 3.3
laryngeal cancer 3.3
MTS 3.3
anthrax 3.3
FMD 3.2
AAA 3.1
head and neck cancer 3.1
plant disease 3.0
Wells 3.0
Tay-Sachs disease 3.0
plague 3.0
SAD 3.0
erythroderma 3.0
latent infection 3.0
adrenocortical carcinoma 3.0
retinitis pigmentosa 2.9
tumor initiation 2.9
Epstein 2.8
AS1 2.8
skin tumor 2.8
NBS 2.8
lymphadenitis 2.8
Robinson 2.8
RSV infection 2.7
toxic shock syndrome 2.7
EBV infection 2.7
MLC 2.6
fungal infection 2.6
tooth loss 2.6
Schistosoma japonicum 2.6
tuberculosis 2.6
Neuroblastoma 2.6
Neuroblastoma 2.6
ADH 2.6
PDB 2.6
keratosis 2.6
typhoid 2.5
PIN 2.5
paracoccidioidomycosis 2.5
endometritis 2.5
tumor vasculature 2.5
SDS 2.5
MRSA 2.5
bacterial endocarditis 2.5
cystic fibrosis 2.4
aspergillosis 2.3
bacteremia 2.3
trisomy 2.3
chronic granulomatous disease 2.3
DDP 2.3
candidiasis 2.3
Cryptococcus neoformans 2.3
hepatoblastoma 2.3
Infections 2.3
enteritis 2.2
EMT 2.2
systemic disease 2.2
Still 2.2
Glioblastoma 2.2
tularemia 2.2
HCC 2.1
Shigella flexneri 2.1
dental caries 2.1
carcinogenesis 2.1
Klebsiella 2.1
skin cancer 2.1
CAP 2.1
gastrointestinal disease 2.1
tumorigenesis 2.1
brucellosis 2.0
NOD 2.0
more...
Symptom
scaly skin 6.3
twitching 5.3
starvation 4.4
general problem 3.9
microbial colonization 3.6
acidity 2.1
acute stress 1.5
hyperoxia 1.3
hypotonia 1.2
exhaustion -0.0
tremor -0.5
diarrhea -0.5
angina -0.7
dyspnea -1.1
collapse -1.1
weakness -1.5
fatigue -2.0
pain -4.3
Drug
Whole human blood 9.4
TMX 7.4
Compound 19 7.2
Flavin 6.9
AraC 6.6
Flavopiridol 6.0
PE2 5.9
Tao 5.1
Doyle 5.0
beta-Galactosidase 4.9
Heme 4.9
OMP 4.8
DNase I 4.8
ABC 4.5
Colistin 4.3
Everolimus 4.3
Gefitinib 3.5
Arsenic trioxide 3.4
Honey 3.3
FeCl3 3.3
NaI 2.9
NaI 2.9
NaI 2.9
NaI 2.9
TTC 2.8
Asn 2.8
PCB 2.6
Gel 2.6
Capsicum 2.5
Glycerol 2.5
TAT 2.5
Fluorescein 2.3
FAD 2.3
Alanine 2.2
lysine 2.1
CaCl2 2.1
CaCl2 2.1
CaCl2 2.0
MRC 2.0
Fluorescein 1.8
p75 1.8
Glutathione 1.3
ampicillin 1.2
Bifidobacterium 1.2
lactose 0.7
Biopolymers 0.6
Nephron 0.6
Ethanol 0.4
NADH 0.3
MAP -0.2
ROS -0.5
caffeine -0.7
Leaf -0.7
IFN-gamma -1.1
IL-2 -1.1
CSF -1.2
Dermatol -3.3
Enzyme
histidine kinase 13.7
choline-sulfatase 13.7
HK3 12.2
EC 5.4.99.15 11.4
5-methylthioribose kinase 10.7
citryl-CoA lyase 10.2
phosphoenolpyruvate-protein phosphotransferase 10.2
N5,N10-methenyltetrahydromethanopterin cyclohydrolase 10.0
SirA 9.6
ent-kaurenoic acid oxidase 9.5
HK2 9.5
K+-transporting ATPase 9.4
ketopantoate hydroxymethyltransferase 9.4
acetone carboxylase 9.4
GMP synthase 8.9
choline monooxygenase 8.6
acetylornithinase 8.4
GMP synthetase 8.0
GMP reductase 7.9
diacetyl reductase 7.8
trehalose synthase 7.6
C5a peptidase 7.4
STK3 7.3
glycerophosphodiester phosphodiesterase 7.3
CFA synthase 7.3
isopentenyltransferase 7.2
xyloglucanase 7.1
cystathionine beta-lyase 7.0
mutarotase 7.0
penicillin binding protein 7.0
arsenite oxidase 6.8
Escherichia coli exonuclease III 6.8
acetate kinase 6.8
MsrB 6.7
aspartokinase 6.6
citrate lyase 6.6
toluene dioxygenase 6.5
LuxS 6.5
pseudouridine synthase 6.4
hexokinase 6.4
cGMP phosphodiesterase 6.4
ACC oxidase 6.3
ScpA 6.3
PME 6.2
pyruvate formate-lyase 6.2
phosphoglyceromutase 6.1
Lod 6.1
endoproteinase Glu-C 6.0
glutamic dehydrogenase 5.9
PRT 5.9
glycerol dehydrogenase 5.9
ADE2 5.8
acylphosphatase 5.8
glycerol dehydrogenase 5.8
histidase 5.8
eEF2 kinase 5.8
formaldehyde dehydrogenase 5.8
clostripain 5.7
malate synthase 5.7
acyl-CoA thioesterase 5.6
pyruvate oxidase 5.6
pyruvate oxidase 5.6
GalT 5.5
dissimilatory sulfite reductase 5.5
serine racemase 5.5
TOR 5.5
LasR 5.5
Pla 5.5
MEKK1 5.4
sortase A 5.4
proline dehydrogenase 5.4
MsrA 5.3
sulfite reductase 5.3
sulfite reductase 5.3
levansucrase 5.3
ceramidase 5.3
sulfite reductase 5.3
Lys4 5.3
fatty acid desaturase 5.2
phosphomannose isomerase 5.2
fructokinase 5.2
hydrogenase 5.1
branched-chain alpha-keto acid dehydrogenase 5.1
hydrogenase 5.1
beta-xylosidase 5.1
transaldolase 5.0
ACC synthase 5.0
succinyl-CoA synthetase 5.0
methanol dehydrogenase 5.0
arginine kinase 4.9
acetyl-CoA synthetase 4.9
lysostaphin 4.8
formate dehydrogenase 4.8
formate dehydrogenase 4.8
lysyl endopeptidase 4.7
SCS 4.7
arginine decarboxylase 4.6
formate dehydrogenase 4.6
HtrA 4.6
estrogen sulfotransferase 4.6
serine hydroxymethyltransferase 4.5
arginine decarboxylase 4.4
cysteine synthase 4.4
fumarate reductase 4.4
polynucleotide kinase 4.3
RNA ligase 4.3
3-hydroxyacyl-CoA dehydrogenase 4.3
pectin methylesterase 4.2
glutamate synthase 4.1
lactic acid dehydrogenase 4.1
MCS 4.1
glutamate synthase 4.1
peptidyl-prolyl cis-trans isomerase 4.1
glutamate synthase 4.0
glyceraldehyde-3-phosphate dehydrogenase 4.0
PST 4.0
PTA 4.0
glycerol-3-phosphate dehydrogenase 3.9
glycerol-3-phosphate dehydrogenase 3.9
IMP dehydrogenase 3.9
chitin synthase 3.9
nitrate reductase 3.8
nitrate reductase 3.8
Rex 3.8
nitrate reductase 3.8
phosphodiesterase 3.8
GAS 3.8
glucokinase 3.8
acetyl-CoA carboxylase 3.8
cystathionine beta-synthase 3.8
nitrate reductase 3.8
ECH 3.7
PAL 3.6
sorbitol dehydrogenase 3.6
phosphoglycerate kinase 3.6
mitogen-activated protein kinase 3.6
PDK1 3.6
GRK5 3.6
fumarase 3.6
RNA polymerase 3.5
arylsulfatase 3.4
pectinase 3.4
RNase T1 3.4
nitrate reductase 3.4
nitrate reductase 3.4
CPS 3.4
cellulose synthase 3.4
chloramphenicol acetyltransferase 3.4
phosphofructokinase 3.4
acyl-CoA synthetase 3.4
transketolase 3.4
PCE 3.3
pyruvate kinase 3.3
SPC 3.3
peroxiredoxin 3.3
asparaginase 3.3
ATPase 3.3
dopamine beta-hydroxylase 3.2
phosphorylase 3.2
guanylate cyclase 3.2
more...
Compound
Fenpiclonil 12.1
Monorden 11.4
cdiGMP 10.7
Subtilin 10.6
Obacunone 9.9
Pyrrolnitrin 9.0
Closantel 9.0
Histidine 8.6
HOG 8.2
Foscan 8.0
Iprodione 8.0
Acetyl phosphate 7.5
Rifamycin 7.3
Rifamycin 7.3
PAS 7.2
Hypericin 7.1
Maltodextrin 7.0
Tazarotene 6.9
Phosphoserine 6.8
Oritavancin 6.7
Rifamycin 6.6
2-Deoxy-D-glucose 6.5
His 6.5
Flavin 6.4
Ethylene 6.4
TIB 6.4
DPS 6.2
Biliverdin 6.1
DGE 6.0
DGE 6.0
DGE 6.0
Daptomycin 6.0
Farnesol 5.9
PRD 5.9
PMB 5.8
G17 5.8
Digitonin 5.7
Rhein 5.6
Mannan 5.6
GMP 5.5
merocyanine 540 5.5
AAB 5.5
AAB 5.5
Na2S 5.5
Honokiol 5.4
TDT 5.3
CAA 5.3
Emodin 5.2
Safranin O 5.2
PTS 5.1
Pyrroloquinoline quinone 5.1
Asp 5.1
Ellagic acid 5.1
Thiocyanate 4.9
Procaine 4.8
PAPS 4.7
OMP 4.7
beta-D-galactoside 4.7
Heme 4.7
B17 4.6
carbamyl phosphate 4.5
glucose-6-phosphate 4.5
DBD 4.5
Arsenite 4.4
CHAPS 4.4
Cefotaxime 4.4
POP 4.4
NTA 4.4
phosphoserine 4.4
MCP 4.3
Methylglyoxal 4.3
Luteolin 4.3
1H-benzimidazole 4.3
aspartic acid 4.2
ATP 4.2
Methicillin 4.1
isonicotinic acid 4.1
homoserine 4.1
homoserine 4.1
threonine 4.1
homoserine 4.1
aspartic acid 4.0
MMA 4.0
aspartic acid 4.0
benzenesulfonamide 4.0
benzenesulfonamide 4.0
glycerol 4.0
benzenesulfonamide 4.0
MAD 4.0
Cysteine 4.0
phosphate 3.9
hydroxycinnamic acid 3.8
tetraphosphate 3.8
malic acid 3.8
malic acid 3.8
D-Ala 3.8
SAD 3.8
betaine 3.8
Ranitidine 3.8
malic acid 3.8
aspartic acid 3.8
FDP 3.8
asparagine 3.7
Collagenase 3.7
Hypo 3.7
serine 3.7
pentose 3.7
pentose 3.7
Genistein 3.7
Epigallocatechin gallate 3.6
pentose 3.6
phenylacetic acid 3.6
Melanin 3.6
phenylacetic acid 3.6
phenylacetic acid 3.6
RDX 3.6
DAP 3.6
DAP 3.6
pentose 3.6
malic acid 3.5
DCC 3.5
methyl methanesulfonate 3.4
phenylacetic acid 3.4
Berberine 3.4
PDB 3.4
chalcone 3.4
cysteine 3.4
PCE 3.4
MES 3.4
phosphoric acid 3.4
MES 3.4
Congo red 3.3
alanine 3.3
Mannitol 3.3
MTS 3.3
PEA 3.3
acetyl-CoA 3.3
Mannitol 3.3
1,3,5-triazine 3.2
1,3,5-triazine 3.2
Agarose 3.2
ABA 3.2
AAA 3.2
PCE 3.2
ETA 3.1
PIN 3.1
Quercetin 3.1
tert-butyl hydroperoxide 3.0
Prednisone 3.0
ADP 3.0
ADP 3.0
ADP 3.0
Biotin 3.0
isocitrate 3.0
isoleucine 3.0
isoleucine 2.9
MIC 2.9
UDP-GlcNAc 2.9
ABA 2.9
1H-imidazole 2.9
more...