Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.13.3 (histidine kinase)
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Chromosomal rearrangements involving mink chromosome 2 in mink-Chinese hamster and mink-mouse hepatoma somatic hybrids were identified. By means of these rearrangements, we assigned the genes for HK1, GOT1, and PP to 2pter----p22, those for PGD, PGM1 and ENO1 to 2q24.4----qter, and that for NP and ADK to 2pter----p11.1.
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PMID:Regional assignments of eight genes on chromosome 2 in the American mink. 386 48

Using Chinese hamster/mouse somatic cell hybrids segregating hamster chromosomes, we assigned 15 enzyme genes to six different Chinese hamster autosomes. Of the 15 loci, three genes, HK1, PEPC, and SORD, were newly assigned to chromosomes 1, 5, and 6, respectively, while ENO1, PGD, and PGM1 were assigned to the long arm of chromosome 2, in the segment 2q113----qter. The locations of the following loci were confirmed: ESD, NP, and PEPB on chromosome 1, ME1 and MPI on chromosome 4, AK1 on chromosome 6, and GPI and PEPD on chromosome 9. Comparative mapping of Chinese hamster and laboratory mouse chromosomes revealed conservation of syntenic groups and extensive banding homology between the Chinese hamster and mouse chromosomes on which homologous enzyme markers have been mapped.
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PMID:Gene mapping in the Chinese hamster and conservation of syntenic groups and Q-band homologies between Chinese hamster and mouse chromosomes. 386 47