Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.13.3 (
histidine kinase
)
2,405
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Many methylotrophs, microorganisms that consume carbon compounds lacking carbon-carbon bonds, use two different systems to oxidize methanol for energy production and biomass accumulation. The MxaFI
methanol dehydrogenase
(
MDH
) contains calcium in its active site, while the XoxF enzyme contains a lanthanide in its active site. The genes encoding the
MDH
enzymes are differentially regulated by the presence of lanthanides. In this study, we found that the
histidine kinase
MxaY controls the lanthanide-mediated switch in Methylomicrobium buryatense 5GB1C. MxaY controls the transcription of genes encoding MxaFI and XoxF at least partially by controlling the transcript levels of the orphan response regulator MxaB. We identify a constitutively active version of MxaY, and identify the mutated residue that may be involved in lanthanide sensing. Lastly, we find evidence to suggest that tight control of active
MDH
production is required for wild-type growth rates.
...
PMID:MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense. 2765 96
